... vinculin and ezrin, which are three well-known actin -binding proteins [6]. The phosphatasesinvolved in this scenario, however, remain unknown and do not require Shp2. Instead, CagAPYcan inhibitSrc ... distribution,making them unsuitable for the investigation of b-cate-nin signalling [29]. In support of this aspect, usingMadin–Darby canine kidney cells that expressE-cadherin and b-catenin without ... revealed the involvement of ADAM17, a metalloproteaseinvolved in catalyzing ectodomain shedding of RTKligands. In nonstimulated cells, ADAM17 is normally in complex with the integrin member...