Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt

... events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant Wance J. J. Firdaus 1 , Andreas Wyttenbach 2 , ... vector, 25Q AC B 10 0 04080 Counts 12 0 16 0 200 10 1 10 2 FL2-H 10 3 10 4 25Q +NAC 72Q 72Q+NAC 10 3Q 10 3Q+NAC 04080 Cou...

Ngày tải lên: 19/02/2014, 06:20

... rat forebrain induces the expression of HSP105 /11 0 family proteins, Hsp105a, APG -1 (testis-specific homologue of Hsp105) and APG-2 [44,45], and Hsp 110 (hamster homologue of Hsp105a) confers heat ... p38 inhibitor. F9, V1, S3 and S23 cells were grown on coverslips, treated with or without 10 l M SB20 219 0 for 1 h before and during the 1 h -treatment with 1 m M hy...

Ngày tải lên: 21/02/2014, 03:20

... ions that differ in mass by 1 Da (replace- ment of one 12 C atom by a single 13 C atom). For 200 400 600 800 10 00 12 00 14 00 16 00 18 00 2000 m/z 0 10 0 % Relative Abundance % Relative Abundance 0 10 0 850 ... scans recorded on [M + 15 H] +15 ions from Rev. For each scan, the reaction time with fluoranthene radical anions was 30 ms. Fragment ions of type c¢ and z...

Ngày tải lên: 18/02/2014, 16:20

... 1. 7 0 0.2 0.4 0.6 0.8 1 1.2 0 10 203040 0 0.2 0.4 0.6 0.8 1 1.2 1. 4 A B 1 10 10 0 10 00 10 000 10 0 000 Time (s) Normalized G(τ) Relative intensity Time (µs) Fig. 5. FCS and FRAP analyses of Olvas–GFP, Nanos–GFP and Tudor–GFP ... assembly and dissociation points. 0 0.2 0.4 0.6 0.8 1 1.2 0 5 10 15 20 0 0.4 0.8 1. 2 1. 6 2A B 1 10 10 0 10 00 10 000 10 0000 Time (s)...

Ngày tải lên: 18/02/2014, 16:20

... a logic formalism introduced in (Dahl & McCord, 19 83), which constit%Ites an extension of the Extraposition Grammar by F. Pereira (19 81) . TNe conjunctions are analyzed by means of a special ... of the whole interpretation process. The rules that are logically contained in that box are the primary tool for performing the syntactic analysis of a sentence...

Ngày tải lên: 21/02/2014, 20:20

... parentheses. Substrate sequence a Type of mutation b k cat /K m (m M )1 Æs )1 ) Wild-type M46L V82S V82A I84V L90M 7. RPGNF-fl-LQSRP (–) 0.8 (1. 0) 0.6 (1. 0) 1. 2 (1. 0) 1. 2 (1. 0) 1. 2 (1. 0) 2 .1 (1. 0) 8. RPGNY-fl-LQSRP (P) 1. 3 (1. 6) ... Director of NIH and by AIDS FIRCA Grant TW 010 01. The contents of this publication do not necessarily reflect the views or policies...

Ngày tải lên: 21/02/2014, 03:20

... P3 2 21 P3 2 21 P3 2 21 P3 2 21 P3 2 21 P3 2 21 a ¼ b(A ˚ ) 87 .16 87.94 88.25 87.26 87.46 88.50 c(A ˚ ) 18 7.42 18 7.55 18 8.29 18 7. 71 185.83 18 7.22 b (°) 12 0 12 0 12 0 12 0 12 0 12 0 Resolution range ... 70.7 Number of atoms Protein 3825 3823 38 21 3828 3828 3853 Water 296 220 215 12 5 59 52 Citrate ion rmsd 11 110 1 Bond length (A ˚ ) 0.006 0.006 0.006 0.00...

Ngày tải lên: 18/02/2014, 16:20

... 0.2 · 10 )13 3 .1 ± 0.4 · 10 )12 L ¼ Cbl – 74 ± 10 4 ± 1 · 10 )7 5 1 10 )15 L ¼ Cbl* – 20–60 10 )5 )10 )6 10 )13 )10 )14 TC + L , TC–L L ¼ CBC 1. 0 ± 0 .1 64 ± 5 4 ± 1 · 10 )7 6 1 10 )15 L ¼ Cbl ... a ´ -ribofuranoside modified cobalamins via 13 C and DEPT NMR. J Org Chem 68, 710 8– 711 1. 21 Seligman PA & Allen RH (19 78) Characterization of...

Ngày tải lên: 19/02/2014, 05:20

... and performance measurement how different stages can correct different types of errors. The resulting accuracy approaches that of individual human an- notators. 1 Introduction High-performance ... information for English, since each of these special characters can also be part of common words. 3 .1 Identification and Classification Errors We begin our error analysis...

Ngày tải lên: 20/02/2014, 12:20

... according to their distributions. Example: A partial character clustering -+ ~: 000000 011 011 1 +-+-+-+ ~lJ 000000 011 1000000 I I +-+- ~ 000000 011 10000 010 I I *- f-~ 000000 011 10000 011 [ ... morphological analysis task can be for- mally defined as finding a set of word segmenta- tions and part -of- speech assignments that maxi- mizes the joint probability of the wo...

Ngày tải lên: 20/02/2014, 18:20