... (2006) 3063–3075 ª 2006 The Authors Journal compilation ª 2006 FEBS 3075
Aggregative organization enhances the DNA end-joining
process that is mediated by DNA- dependent protein kinase
Masahiko Takahagi ... state.
A further concern is whether the protein kinase
activity of DNA- PKcs is really associated with the EJ
reaction in the context of protei...
... PG
headgroup, but that the negatively charged phosphate is
important for the enzyme.
DGlcDAG synthase (II) is activated by PG or CL in the
same way as MGlcDAG synthase, but also by other
phosphate-containing ... 2003 Lateral organization of A. laidlawii lipids (Eur. J. Biochem. 270) 1701
The response(s) Y is then fitted to the variables by a
mathematical model, e.g. Y...
... blot
[32]
Gadus morhua G Testis and ovary During
spermatogenesis
Germ cells
(testis and ovary)
PCR, ISH [25]
Gobiocypris rarus G Testis – n.i. PCR [19]
Halichoeres tenuispinis pG Testis – Northern blot [33]
Monopterus ... [35].
Although this observation might lead to the assump-
tion that germline expression is dispensable, condi-
tional dmrt1 inactivation in either the Sertoli cells...
... [26]. These findings
lead to the hypothesis that Fe-bound ApeSOD mimics
the product-inhibited form and the shift of Tyr39 sup-
presses the release of the peroxide product. This may
be one of the ... The metal-specificity
of cambialistic SODs can be suppressed by mutagene-
sis at a site 11 A
˚
away from the reaction center, as
reported for the P. gingivalis SOD [7]. This su...
... nmol.
The reasons for this suprising drop in the radical con-
centration during substrate conversion are given in the
discussion.
Discussion
There is a growing body of evidence suggesting that
the ... activity is
restored. By not adding the reductant, the expectation
is that only one turnover of the enzyme is possible.
However, it is still expected that tyrosyl...
... dynamics simulations. The results predicted that
the mutant G194P had the decreased conformational fluctuation in the
loop region and might increase the thermostability of Ochr-MPH. The
thermostability ... to test the effect of the mutations; the mutant
G194P was predicted to have increased thermostabil-
ity. This prediction was also supported by experimen-
tal data on t...
... ferredoxin, to drive the energy-demanding
pyruvate synthesis by POR. We demonstrate that H. thermophilus POR
catalyzes pyruvate synthesis from acetyl-CoA and CO
2
, confirming the
operation of the reductive ... demonstrate that
H. thermophilus POR functions toward pyruvate syn-
thesis in vivo.
To investigate the reaction mechanism of H. thermo-
philus POR, we measured the EPR s...
... apoptosis, the relationship of these two molecules is still
largely unknown. The aim of the current study was to investigate the
potential involvement of nucleolin ⁄ C23 in the antiapoptotic mechanism ... against the H
2
O
2
-induced apoptosis. These
data suggest that Hsp70 may inhibit apoptosis at
multiple points and through a wide range of
mechanisms.
Nucleolin is a major...
... ed 3 phuang thdc the bien
tren sdng:
dpe,
dpe
kit hpp vdi
noi va noi (dng khiu).
LDgc
Ekyc-
theo td didn tieng Viet,
li phit thinh lii nhung dieu di
dupe
viii
ra,
theo dung trinh
... trong vdn ban
quy djnh each dgc cua nha bdo.
Ngudi dgc khdng the tuy tien
ngdt cdu, ngat doan, ngtmg nghi
theo y thich, ma phai men theo
dau chdm, ddu phay, cdch su
dung ngd doan eua tdc g...
... containing the mutations of the
miR-23a binding site (Fig. 4A). It was shown that
miR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the
intensity of EGFP fluorescence in the vector bearing
the mutant of the ... 4B, C).
These observations suggest that miR-23a binds mainly
to the first targeting site of the IL6R mRNA 3¢ UTR
and represses gene expression. These data highlight the...