Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx

... ª 2006 The Authors Journal compilation ª 2006 FEBS 299 Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles Elizabeth C. Banks 1 , Stephen W. Doughty 2, *, ... structure of B12-binding domains of methionine synthase. Science 266, 1669–1674. 5 Dixon MM, Huang S, Matthews RG & Ludwig M (1996) The structure of the C-terminal...

Ngày tải lên: 19/02/2014, 05:20

... lysis) of the cell wall is an essential process for both cell viability and liberation of viru- lence factors. Inhibition of autolysis by excess cho- line might, in the first instance, seem to be of therapeutic ... situation. Dimerization of C-LytA The occupation of high-affinity binding sites by choline triggers the dimerization of C-LytA [21]. The effect of bicyclic amin...

Ngày tải lên: 19/02/2014, 05:20

... inhibition of FNR by Zn-ferrocyanide. More remark able, the solely polypeptide interaction between FNR a nd apoFld is su fficient to p revent the inhibition, indicating that no participation of ... Trippi, V.S. (2000) Inhibition of wheat nitrate reductase a ctivity by zinc. B iol. Plant. 43 , 257–262. 21. Egash ira, T., Takayama, F . & Sakai, K. (2003) Inhibition by Zn (...

Ngày tải lên: 19/02/2014, 16:20

... inactivation of G APDH being metal- ion independent, whereas inhibition of GR and LDH by H 2 O 2 occurs most rapidly in the presence of metal ions. It is proposed that the inhibition of GAPDH and GR by these 1 O 2 -generated ... concentrations of H 2 O 2 needed to be employed to generate a similar r ate and extent of inhibition (Fig. 4 B). Inhibition by protein-deriv...

Ngày tải lên: 21/02/2014, 03:20

... solu- tion of ThT and the fluorescence intensity of the solu- tion was measured at 482 nm. Figure 4A shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... was incubated in the absence of MPTP. When a-synuclein was incubated alone in the presence of dopamine, it led to inhibition of fibrillation, probably by the accu- mulat...

Ngày tải lên: 14/02/2014, 19:20

... F 0 F 1 -ATP synthase activity mediated by a relief of inhibition by cyclophilin D was evident in the form of slightly increased respiration rates during arsenolysis. However, the modulation of F 0 F 1 -ATP synthase ... CYPD or its inhibition by cyclosporin A significantly enhanced the rate of F 0 F 1 -ATP synthase- mediated regeneration of ATP consumed by arsenolysi...

Ngày tải lên: 14/02/2014, 19:20

... (Tdag51) by direct HSF1 binding of a HSE in the proximal promoter region of the Tdag51 gene. Tdag51 is a member of the PHL domain family and its N-terminal region is bound and inhibited by major ... elongation, inhibition of denucleation and of loss of organelles [101]. In line with this phenotype, fibroblast growth factor (FGF)-4 and FGF-7, which control the proliferation an...

Ngày tải lên: 18/02/2014, 04:20

... & Bjork I (2000) Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110. FEBS Lett 487, ... the presence of various concentrations of 2A2 mAb. The binding of 2A2 mAb was followed by native gel elec- trophoresis. Increasing the concentration of 2A2 mAb at a fixed mo...

Ngày tải lên: 18/02/2014, 11:20

... hydrolysis of triolein by purified recombinant rat adipocyte HSL, with a decrease in the effect of bis-ANS upon PKA phosphorylation of HSL. The interaction of HSL with bis-ANS was found to have a K d of ... typically incubated for a period of 30 min at 37 °C before the reaction was quenched by the addition of 3.25 mL of methanol ⁄ chloroform ⁄ heptane (10 : 9 : 7) and 1.1 m...

Ngày tải lên: 18/02/2014, 11:20

... Regulation of mitochondrial respir- ation by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 1504, 46–57. 20 Cadenas E, Poderoso JJ, Antunes F & Boveris A (2000) Analysis of ... presence of this enzyme in different tissues with properties of endothelial NOS, nNOS, and ⁄ or iNOS [14,31,32]. In different models of sepsis and tissues, the existence of...

Ngày tải lên: 19/02/2014, 00:20