Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... ª 2006 The Authors Journal compilation ª 2006 FEBS Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling Sandra Kleiner, Amir Faisal* and Yoshikuni ... clear that the expression of E-cadherin and the expression of MMPs are inversely correlated [11,12] and that E-cadherin- dependent cell–c...

Ngày tải lên: 19/02/2014, 05:20

... to the sequence of the hsp70 promoter between )206 and )187 bp, and that mutations of this sequence abrogated the activation of the hsp70 promoter by Hsp105b. In addition, overexpression of Hsp105b stimulated ... Hsp105b stimulated the phosphorylation of STAT3 at Tyr705 and its translocation to the nucleus. Downregulation of STAT3 expression resulted in reduc...

Ngày tải lên: 18/02/2014, 06:20

... Model of the 3D structure of the neutral protease from Bacillus stearothermo- philus, including the position of the disulfide bridge in mutant G8C ⁄ N60C. The model was created on the basis of the ... fluorescence and CD spectra of the unfolded and the degraded protein are nearly identical [15], the progress curves in the presence of GndHCl reflect the dec...

Ngày tải lên: 19/02/2014, 17:20

... develop a broader perspective of the questions within an analysis of the hypothesis in the con- text of a characterization of the "how" of the entire behavior. By adapting HOPE for processing ... process time interval, there are six types of serial-order process that can occur and affect the state of the process. The most important aspect of...

Ngày tải lên: 21/02/2014, 20:20

... rest of the input data if the workflow is robust (i.e. makes use of retry and parallelisation) and the error is confined to a WS (i.e. it does not affect the rest of the workflow). An instance of ... and one of my- Experiment have been deployed to be the Reg- istry and the portal to share workflows and other experiment-related data. Both have been adapted by mo...

Ngày tải lên: 22/02/2014, 03:20

... reference, the position of the sugar and of the metal in the crystallo- graphic template 1YOE. The two ligands were modelled in each binding site of SsCU-NH, and then the structure of the resulting ... pro- trudes towards the exterior of the tetramer near loop 275–288 of the opposite monomer. Therefore, the binding and adaptation of this portion of...

Ngày tải lên: 18/02/2014, 17:20

... without the need for PI-3¢ kinase activity as judged from the absence of an effect of arsenite on PI-3¢ kinase activation and the lack of inhibition by either wortmannin or LY 294002. Furthermore, ... uptake. Another early target of insulin action, the activation of ERK- 1, -2 was also not activated appreciably in response to arsenite-treatment either (Fig. 3D). The e...

Ngày tải lên: 21/02/2014, 00:20

... THP-1 monocytes. In addition, the effects of KLF4 on the expression of SR-BI and the primary mechanism were also investigated. Results HDL induces the expression of KLF4 and SR-BI in PBMC and phorbol 12-myristate ... demonstrated the increasing expression of KLF4 in PBMC and THP-1 cells, and identified that induction of KLF4 by HDL 3 promoted the expr...

Ngày tải lên: 18/02/2014, 04:20

... of this type exhibit the predicted amount of binding only if the heterodimer is tethered by the wild-type partner. By contrast, we found that, if the heterodimer is tethered to the resin by the ... employing soluble forms of the receptor [25,26,34], indicates that the ectodomain of the receptor is capable of dimer forma- tion in the absence of ligand. Affi...

Ngày tải lên: 18/02/2014, 08:20

... significantly increases the cost of the purification, and the require- ment for HPLC increases the length and complexity of the purification procedure. Moreover, as with the studies by Lee et al. [21] and Subramanian ... E22K, E22Q and D23N), and the availability of a rapid and simple expression and purification protocol will facilitate large-scale investigat...

Ngày tải lên: 18/02/2014, 13:20