Tài liệu Báo cáo khoa học: Oxidation inhibits amyloid fibril formation of transthyretin ppt

... and the kinetics of fibril formation of these oxidized proteins reveal the amino acid inter- actions that are critical in the onset of amyloido- genesis. The rates of amyloid fibril formation for ... tissues including amyloid fibrils [7,8]. We are investigating the role of amino acid side chain oxidation in amyloid assemblies by comparing the kinetics of fibril...

Ngày tải lên: 19/02/2014, 05:20

... Similarity Akira Utsumi and Daisuke Suzuki Department of Systems Engineering The University of Electro-Communications 1-5-1 Chofugaoka, Chofushi, Tokyo 182-8585, Japan utsumi@se.uec.ac.jp, dajie@utm.se.uec.ac.jp Abstract This ... process- ing. Other methods use a variety of other informa- tion: cooccurrence of two words (Burgess, 1998; Sch¨utze, 1998), occurrence of a word in the se...

Ngày tải lên: 20/02/2014, 12:20

... death [27]. The functional roles of the activation of these kinases are often con- troversially discussed. The ERK1 ⁄ 2 cascade is regarded to be the main method of transmission for cell proliferative ... with 500 lL of NaCl ⁄ P i and 10 mL of 70% eth- anol at 4 °C overnight; then, after washing twice with NaCl ⁄ P i , the cells were incubated with 1 mL of PI staining solution (50...

Ngày tải lên: 18/02/2014, 13:20

... illustrating needle and translocon formation, as well as toxin secretion steps, in the T3SS of P. aeruginosa (a rep- resentative of the Ysc T3SS family). (A) Upon formation of the base rings (green), ... and response to pore formation The composition of the host cell membrane appears to be a critical point for the invasion of bacteria, insertion of translocators and functiona...

Ngày tải lên: 14/02/2014, 22:20

... because of its higher fold of upregula- tion in gastric adenocarcinoma tissues. Although the extent of upregulation of miR-23a in the four pairs of gastric tissues showed great variance because of the ... the active role of miR-23a in the growth promotion of malignant cells. The fundamental function of miRNAs is to regulate their targets by direct cleavage of mRNA or by in...

Ngày tải lên: 18/02/2014, 04:20

... Ollivaux C & Soyez D (2000) Dynamics of biosynthe- sis and release of crustacean hyperglycemic hormone isoforms in the X-organ-sinus gland complex of the crayfish Orconectes limosus. Eur J ... Soyez D (2002) Enkephalinergic control of the secretory activity of neu- rons producing stereoisomers of crustacean hyperglyce- mic hormone in the eyestalk of the crayfish Orconectes lim...

Ngày tải lên: 18/02/2014, 11:20

... with 55 mL of the same buffer, first alone and then with a 200 mL of a decreasing gradient of ammonium sul- phate in 20 mm Tris⁄ HCl buffer (pH 8.0) with a flow of 0.8 mLÆmin )1 . Fractions of 2.5 ... tryptophol (17). Moreover, the rates of transformation of both compounds 8 and 16 in fungal cultures were substan- tially slower than the rates observed for transformation of brass...

Ngày tải lên: 18/02/2014, 14:20

... was composed of 2 lL of Moloney murine leukemia virus reverse transcriptase buffer; 0.5 lL of BSA (10 mgÆmL )1 ), 1 lL of total RNA (1.24 lgÆlL )1 ), 2.5 lL of dNTP (4 mm total), 1.5 lL of Random ... overexpression approach of RpCAbr and RpCAtr, we cannot know the functional effect of changes of some key amino-acids. Origin and number of nonvertebrate CAs Although the boot...

Ngày tải lên: 18/02/2014, 16:20

... nanosecond timescale. The lack of fast internal motions reflects the crucial role of Gln50, which behaves as mechanical point of support, needed for the hinging of the C-ter- minal part of helix III. This ... well-known class of DNA-binding domains occurring in a large family of transcription activators involved in the determination of cell development [1–3]. The tertiary struc...

Ngày tải lên: 18/02/2014, 16:20

... exhibited a mass shift of 32. The unequivocal assignment of two oxygen atoms to the Cys175 residue of C53S 2-Cys Prx revealed the unsuspected formation of oxyacid groups at sulfur atoms of the resolving ... concurrent displacement of the A C B Fig. 2. Effect of the binding of ATP ⁄ Mg 2+ to 2-Cys Prx on the fluo- rescence emission of extrinsic and intrinsic chromophores. (A...

Ngày tải lên: 18/02/2014, 17:20