Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

... The Authors Journal compilation ª 2006 FEBS DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner Hana Pivon ˇ kova ´ 1 , ... modification with the antitumor drug cisplatin inhibits p53 binding to a synthetic p53 DNA- binding site. Here we demonstrate that the effects o...

Ngày tải lên: 19/02/2014, 05:20

... RNA-cleaving activity in a self-cleaving DNAzyme. The DNAzyme with DNA- cleaving and RNA-cleaving activities was constructed by incorporating the catalytic domain of 8–17 variant DNAzyme into the ... insights into the engineering of DNAzymes. Experimental procedures Materials The DNA sequences (PL DNAzyme, 5¢-GAATTCTAATAC GACTCAGAATGAGTCTGGGCCTCTTTTTAAGAAC-3¢; 8–17 variant DNA...

Ngày tải lên: 16/02/2014, 15:20

... the range of 5–10 kDa, typically including two dominating peaks at approximately m ⁄ z 7000. As mycelia and spores largely remained intact, and the extraction solution contained acetonitrile and ... and 7521 appearing (Fig. 4B). To obtain a preliminary correlation of observed masses with hydrophobin data, we again calculated from the available sequence data sets of masses fo...

Ngày tải lên: 19/02/2014, 02:20

... peptides are involved in a variety of neuronal and endocrine functions, including regula- tion of appetite and circadian rhythm, as well as cardiovascular, reproductive and gastrointestinal func- tions ... 2048–2063 ª 2006 The Authors Journal compilation ª 2006 FEBS 2059 used: forward primer 5¢- CAATTGGGAAGAAAACCAG ACA and reverse primer 5¢- GCACAATGTATTCACCAG CAGA. Actin, use...

Ngày tải lên: 19/02/2014, 07:20

... the thin layer chromatography plates, the metabolites were quantified by scraping the radioactive areas and counting with a Wallac 1410 counter. Substrate-induced binding spectra Spectral titrations ... DDT. Substrate binding The substrate induced binding spectra associated to DDT and to testosterone are type I spectra (data not shown) and Fig. 1. Production of the CYP 6A2 va...

Ngày tải lên: 19/02/2014, 12:20

... ACL. Karolina Owczarzak, Josef van Genabith, and Andy Way. 2007. Labelled dependencies in machine translation evaluation. In Proceedings of the Second Workshop on Statistical Machine Translation. Sebastian ... L. Micciulla, and J. Makhoul. 2006. A study of translation edit rate with targeted human annotation. In AMTA. Valentin I. Spitkovsky, Hiyan Alshawi, and Daniel Juraf...

Ngày tải lên: 19/02/2014, 19:20

... binding revealed decreased affinities and positive cooperativity. Thus, mutations in this interface can in uence DNA binding as well as effector binding, albeit both ligand binding sites are not in direct ... is increased, leading to loss of DNA binding. Helices a1 , a4 and a6 forming this interface are involved in signal transduction, but there is no structural hin...

Ngày tải lên: 20/02/2014, 01:20

... iterations. Table 1 compares training time (10 iterations) and parsing time of a parser using a CW-classifiers and a parser using SVM on the same data set. We see that training of the CW- classifier ... results have been ob- tained using margin-based machine learning ap- proaches. For the MST-parsing MIRA (McDonald et al., 200 5a; McDonald and Pereira, 2006) and for transition...

Ngày tải lên: 20/02/2014, 04:20

... Eliminating alphabet storage In this kind of hashing tricks, an index of inputs do not have to be an integer but can be any hash- able value, including a string. Ganchev and Dredze (2008) argued this property ... 2003; Boutsidis et al., 2010), feature hashing retains spar- sity of sparse input vectors. An additional useful trait for NLP tasks is that it can save much memory by eli...

Ngày tải lên: 20/02/2014, 05:20

... Graphs Fangtao Li, Yang Tang, Minlie Huang, and Xiaoyan Zhu State Key Laboratory on Intelligent Technology and Systems Tsinghua National Laboratory for Information Science and Technology Department ... the topic score and the opinion score are usually separately calculated and then combined via a linear combination (Varma et al., 2008) or just filter out the candidate without match...

Ngày tải lên: 20/02/2014, 07:20