Tài liệu Báo cáo khoa học: Bone morphogenetic protein signaling in stem cells ) one signal, many consequences pptx

... 2975 MINIREVIEW Bone morphogenetic protein signaling in stem cells ) one signal, many consequences Toni U. Wagner Physiological Chemistry I, University of Wuerzburg, Germany BMP signals in stem cells Bone ... & Izpisua Belmonte JC (200 6) Nanog binds to smad1 and blocks bone morphogenetic protein- induced T. U. Wagner BMP signaling in stem...

Ngày tải lên: 19/02/2014, 00:20

... family, binding to and inhibit- ing these signaling molecules from binding to their receptors in the extracellular space, thus inhibiting ven- tralizing activities. Of these proteins, Chordin has ... understanding of BMP func- tions, in combination with other experimental techniques. Abbreviations ADMP, anti-dorsalizing morphogenetic protein; BMP, bone morphogenetic protein; TGF...

Ngày tải lên: 19/02/2014, 00:20

... the properties of the three protein classes, with the main focus being on RNA chaperones and annealer proteins. Specifically binding proteins A specific protein cofactor binds to its RNA target through ... this kinetically limiting process occurs in vivo, proteins (called RNA chaper- ones) have evolved that facilitate the (re)folding of RNA molecules. Here, we present an overview of how p...

Ngày tải lên: 14/02/2014, 19:20

... with thrombin alone (4 n M) or in combination with ADP (20 lM). (A) Effect of AR-C (10 lM) preincubation on Ca 2+ response. (B) Effect of general PI3-K inhibitor LY294002 (LY, 25 lM)onCa 2+ response. ... [Ca 2+ ] i -time integrals over 5 min. *P < 0.05, **P < 0.1 (n = 3– 5). Agonist Antagonist Peak (n M) (% versus thrombin) Integral (nM · s) (% versus thrombin) Thrombin Vehicle 646...

Ngày tải lên: 18/02/2014, 16:20

... spanning 39 bp in the proximal region of the fgl2 promoter. As shown in Fig. 4, mutating nucleotides from )8 7 to )8 0 (containing Oct- 1), )7 7 to )7 1 (containing Sp 1), )6 8 to )5 7 (containing Ets/Stat 3) ... cyto- toxin, and fibrinogen [16–18]. Fibrinogen-like protein family members all contain fibrinogen-related domains (FRED), known to represent key regions...

Ngày tải lên: 20/02/2014, 11:20

... mitogen-activated protein kinases (MAP- Ks), MPK3 and MPK6, in response to oxidative stress. In addition, the serine ⁄ threonine protein kinase Pto-interacting 1-2 (PTI1- 2) has been positioned downstream ... protein kinase; MAPKK, mitogen-activated protein kinase kinase; MBP, myelin basic protein; OXI1, oxidative signal-inducible 1; PDK1, 3-phosphoinositide-dependent kinase 1...

Ngày tải lên: 14/02/2014, 19:20

... obtained by flow cytometric analysis in the FL1 channel (logarithmic scale). Control (Ctrl) cells (blue line), stearate-treated cells (green line), oleate (OA)-treated cells (black line) and cells ... isothiocyanate (FITC) (BD Pharmigen, San Diego, CA, USA) binding and PI staining were performed according to [44]. Following incubation with 1.0 lgÆmL )1 annexin V and 4.0 lgÆmL )...

Ngày tải lên: 14/02/2014, 22:20

... EGFR (including EGF, transforming growth factor-a, amphi- regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin ... ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains....

Ngày tải lên: 16/02/2014, 09:20

... (EGFR-TKIs), gefiti- nib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways ... results in EGFR signaling pathways being turned off and the cancer cells undergoing apoptosis. Moreover, EGFR mutations result in repositioning of critical residues surrounding the ATP-...

Ngày tải lên: 16/02/2014, 09:20

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... (HMG) domains are involved in binding DNA with low sequence specificity. LXXLL domains (also known as the NR box) are involved in interaction with nuclear receptor (NR). Plant homodomain (PH...

Ngày tải lên: 16/02/2014, 14:20