Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx

... 3093 The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor Jacky Bonaventure 1,2 , Linda Gibbs 2 , ... 3 (FGFR3) mutations have been ascribed to skeletal dysplasias of variable severity including the lethal neonatal thanatophoric dysplasia...

Ngày tải lên: 19/02/2014, 00:20

... recognition could not be blocked by pre-incubation with PRiMA antigen. These results clearly indicate the specificity of the PRiMA antibody in recognizing the cytoplasmic domain of PRiMA I. According ... regulation of PRiMA is down-regulated during myogenic differentiation and under the influence of innervation [9]. In line with the transcriptional expres- sion of PRiMA,...

Ngày tải lên: 18/02/2014, 08:20

... Asn334, is conserved in all subunit types (Hc1 and Hc2) with the exception of PmaHc1. An insertion of nine amino acids in PamHc2 starting at amino acid 435 is unique to subunit types 2. On the amino ... the hexamerins of the dicondylian insects (Fig. 2). Hemo- cyanins and hexamerins share many characteristics in Fig. 3. Occurrence of both hemocyanin subunit types in Hexapo...

Ngày tải lên: 18/02/2014, 08:20

... specifically increase the activity of aB-crystallin against DTT-induced precipi- tation of insulin at intermediate and high concentra- tions, and it also increased the activity of aB-crystallin in preventing ... against the DTT-induced aggregation and precipi- tation of insulin. A C B Fig. 2. aB-crystallin protects against the DTT-induced aggregation of insulin, and t...

Ngày tải lên: 18/02/2014, 16:20

... processes of its folding and unfolding is a prerequisite for under- standing the epigenetic regulation in cell differentiation. Although the shape of the fibre and its dimensions and mass per unit length ... product of MNase digestion of all the fractions, including S, is mononu- cleosome size DNA and the ten nucleotide periodicity is preserved in the DNase I dige...

Ngày tải lên: 18/02/2014, 18:20

... reduction in the binding affinity was observed in the case of binding of the M.HhaI with the X + CG ⁄ CGM duplex containing the (+)-cis-B[a]P- N 2 -dG adduct on the 5¢-side of the target dC residue. The ... contacts with the catalytic loop of the enzyme from the DNA minor-groove side. The contacts of the amino-acid A B CD Fig. 3. Equilibrium competitive bind...

Ngày tải lên: 19/02/2014, 00:20

... RNases’ EIE max values and their positive net charges, but also with their ability to destabilize a membrane. We then considered the possibility of a correlation between the cytotoxic action of the investigated dimeric RNases ... prototype, has interested and intrigued investigators. Their ribonucleolytic activity is essential for their cytotoxic action, and their target RNA i...

Ngày tải lên: 19/02/2014, 06:20

... degradation and repair in ageing and oxidative stress B. Friguet Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement, Universite ´ Denis Diderot – Paris 7, Paris, France. E-mail: bfriguet@paris7.jussieu.fr Cellular ... decreased elimination of oxidized protein. Since the proteasome is in charge of protein turn- over and removal of oxidized protein, its fate during...

Ngày tải lên: 19/02/2014, 07:20

... density of RTA R213D in the vicinity of residue 213. The backbone and sidechains of the R213D substitution are shown as stereo images in thick ball and stick and the position of the Arg213 side-chain ... substitution are shown as stereo images in thick ball and stick and the position of the Asn122 side-chain of the wild -type enzyme is overlayed and sh...

Ngày tải lên: 19/02/2014, 12:20

... [3], and Chlamys islandica [4,5]. These authors noticed the striking similarity between the bivalve lysozyme and another protein, the so-called desta- bilase identified in the medicinal leech Hirudo ... database of the National Center for Biotechnology Information (NCBI) shows significant sequence similarities with the destabilase of the medicinal leech H. medicinalis [7],...

Ngày tải lên: 19/02/2014, 12:20