... different intracellular proteins, namely FK506- binding protein (FKBP) and cyclophilin, and thedrug–protein complex then binds to the interface of thecalcineurin A ⁄ B complex and blocks its phosphataseactivity ... expression of genes such as IL-2,IL-3, GM-CSF, IL-4, IL-5, IL-13, IFN-c, TNF-a,CD40 ligand and Fas ligand, etc. (Fig. 3). Ligand bind-ing of various receptors results in the activation of phospholipase ... We tested the effect of PPAR-a and PPAR-cligands in vivo on the progression and severity of adju-vant-induced arthritis in female Lewis rats and foundthat pioglitazone and fenofibrate suppressed...