Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc

Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc

Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc

... 2008 The Authors Journal compilation ª 2008 FEBS Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis Holger Hetschko 1 , Valerie Voss 1 , Volker ... receptor 5 (DR5) revealed that reactivation of TRAIL- induced apoptosis by proteasome inhibitors depended on enhanced tran- scription and surface expression...

Ngày tải lên: 18/02/2014, 17:20

12 440 0
Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx

Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx

... this type of regulation has to be elucidated further. Acetylcholine esterase inhibitors, which are already used in the symptomatic treatment of AD, enhance the transport of ADAM10 to the cell surface ... receptors. In the case of ADAM10 regulation, cell culture studies with a variety of ligands for nuclear receptors narrowed the receptors involved down to a nonpermissive ret...

Ngày tải lên: 16/02/2014, 09:20

12 591 0
Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx

Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx

... Before MS analysis, all samples were stored at )30 °C. MALDI-TOF ⁄ TOF MS analysis Analysis of the digests was conducted by of ine nano- HPLC ⁄ MALDI-TOF ⁄ TOF MS, using a nanoHPLC sys- tem (Ultimate ... signals with signal -to- noise ratio higher than 10 were automatically subjected to MALDI-LIFT-TOF ⁄ TOF MS ⁄ MS experiments by applying 2000 laser shots. NanoHPLC–nanoESI–qTOF MS a...

Ngày tải lên: 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx

Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx

... lipids further away tend to occupy areas close to the bulk value of DPPC. In Fig. 5, lipids of the top leaflet were ordered according to their proximity to the center of mass of the Ab pep- tide. ... experienced by the nearby lipids to the motion and tilting of this embedded segment. Thinning of the bilayer in the presence of Ab40 Because Ab40 is known to disrupt th...

Ngày tải lên: 18/02/2014, 08:20

16 475 0
Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

... Hall of Fame, according to their total credits to provide an incentive for them to play the game after school. In Figure 1, the player has to hit the monster be- fore the monster disappears to ... Learning to read and write Chinese characters is a challenging task for learners of Chinese. To read everyday news articles, one needs to learn thou- sands of Chinese char...

Ngày tải lên: 19/02/2014, 19:20

6 590 0
Tài liệu Báo cáo khoa học: "Seeing stars: Exploiting class relationships for sentiment categorization with respect to rating scales" doc

Tài liệu Báo cáo khoa học: "Seeing stars: Exploiting class relationships for sentiment categorization with respect to rating scales" doc

... class labels of the pair grow farther apart. shows that in aggregate, the vocabularies of distant classes overlap to a degree surprisingly similar to that of the vocabularies of nearby classes. ... viewed disjoint document sets, since we wanted to maximize experi- mental coverage of the types of document pairs within each dif- ference class. We thus cannot report inter-annot...

Ngày tải lên: 20/02/2014, 15:20

10 511 0
Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy- ses of SERCA were performed with the data obtained in the pres- ence of ... correspond to the velocity of the catalytic cycle of SERCA. Interestingly, the turnover rate, ATP concentration dependency and TG inhibition of up–down motion are quite similar t...

Ngày tải lên: 14/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... (2003) Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. J Pharmacol Exp Ther 304, 1048–1054. 27 Kumar H, Kawai T & Akira S (2009) Toll-like recep- tors ... regulations were attributed to the ability of KCs to develop exaggerated inflammatory responses through TLR overexpression, the release of HMGB1 and the upregulation of...

Ngày tải lên: 14/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

... parts of the protein molecule (e.g. either pro- tonation of a number of side chains, binding of metals to an unfolded state or mutations at specific sites) are key to amyloid formation. One of the ... unfold- ing of the a-helix from the body of the b-sheet (Fig. 2C). Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formatio...

Ngày tải lên: 14/02/2014, 18:20

20 756 0
Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... nonamy- loidogenic but cytotoxic [14,18]. In the presence of MPTP, dopamine accelerated the rate of fibrillation, leading to a higher rate constant of aggregation. Because accumulation of the toxic protofibrils ... dopamine–quinone adducts (because of auto-oxidation of the neurotrans- mitter), especially dopaminochrome, with a-synuclein, inhibited the conversion of the more-toxi...

Ngày tải lên: 14/02/2014, 19:20

11 754 0
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