Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc
Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc
... 2008 The Authors Journal compilation ª 2008 FEBS Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis Holger Hetschko1, Valerie Voss1, Volker ... receptor 5 (DR5) revealed that reactivation of TRAIL-induced apoptosis by proteasome inhibitors depended on enhanced tran-scription and surface expression of DR5. Transient knockdown of thetranscription ... aclear trend towards an apoptosis- inhibitory effect of the DR5 knockdown, indicating that basal expression of DR5 is required for the TRAIL sensitivity in these cells. Apoptosis induced by TRAIL...
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Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx
... this type of regulation has to be elucidated further. Acetylcholine esterase inhibitors, which are already used in the symptomatic treatment of AD, enhance the transport of ADAM10 to the cellsurface ... receptors. In the case of ADAM10 regulation,cell culture studies with a variety of ligands for nuclearreceptors narrowed the receptors involved down to a nonpermissive retinoic acid receptor–retinoidX ... substrates: ectodo-main shedding by ADAM10 is followed by regulatedintramembrane proteolysis. After cleavage of theNotch receptor by ADAM10, c-secretase releases asmall intracellular part of Notch,...
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Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx
... Before MS analysis, allsamples were stored at )30 °C.MALDI-TOF⁄TOF MS analysisAnalysis of the digests was conducted by of ine nano-HPLC ⁄ MALDI-TOF ⁄ TOF MS, using a nanoHPLC sys-tem (Ultimate ... signals with signal -to- noise ratio higher than 10 were automatically subjected to MALDI-LIFT-TOF ⁄ TOF MS ⁄ MS experiments by applying2000 laser shots.NanoHPLC–nanoESI–qTOF MS analysisOn-line ... formation of pyroglutamic acid moieties from Gluand Gln were considered as variable modifications.Moreover, automated de novo sequencing of the nano-ESI–qTOF and MALDI-TOF ⁄ TOF MS data followed by database...
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Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx
... lipids further away tend to occupy areas close to the bulk value of DPPC. InFig. 5, lipids of the top leaflet were ordered according to their proximity to the center of mass of the Ab pep-tide. ... experienced by the nearbylipids to the motion and tilting of this embeddedsegment.Thinning of the bilayer in the presence of Ab40Because Ab40 is known to disrupt the integrity of thelipid ... integrity of the plasma membrane,Ab promotes the increased leakage of ions, particularlycalcium, into the cell [10]. The disruption of calciumhomeostasis, and thus the promotion of neuronalexcitotoxicity,...
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Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc
... Hall of Fame, according to their total credits to provide an incentive for them to play the game after school. In Figure 1, the player has to hit the monster be-fore the monster disappears to ... Learning to read and write Chinese characters is a challenging task for learners of Chinese. To read everyday news articles, one needs to learn thou-sands of Chinese characters. The official ... Authoring Tool for the Games Our game platform has attracted the attention of teachers of several elementary schools. To meet the teaching goals of teacher in different areas, we have to allow...
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Tài liệu Báo cáo khoa học: "Seeing stars: Exploiting class relationships for sentiment categorization with respect to rating scales" doc
... class labels of the pair grow farther apart.shows that in aggregate, the vocabularies of distantclasses overlap to a degree surprisingly similar to that of the vocabularies of nearby classes. ... vieweddisjoint document sets, since we wanted to maximize experi-mental coverage of the types of document pairs within each dif-ference class. We thus cannot report inter-annotator agreement,116Because ... All of the1770, 902, 1307, or 1027 documents in a given cor-pus were written by the same author. This decisionfacilitates interpretation of the results, since it fac-tors out the effects of...
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Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt
... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy-ses of SERCA were performed with the data obtained in the pres-ence of ... correspond to the velocity of the catalytic cycle of SERCA. Interestingly, theturnover rate, ATP concentration dependency and TGinhibition of up–down motion are quite similar to those of ATPase ... Motion of the Ca2+-pump capturedMasatoshi Yokokawa1,2and Kunio Takeyasu11 Kyoto University Graduate School of Biostudies, Japan2 Graduate School of Pure and Applied Science, University of...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... (2003)Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. JPharmacol Exp Ther 304, 1048–1054.27 Kumar H, Kawai T & Akira S (2009) Toll-like recep-tors ... regulations were attributed to the ability of KCs to develop exaggerated inflammatory responsesthrough TLR overexpression, the release of HMGB1and the upregulation of proinflammatory cytokines.Materials ... activation of KCs[25]. The expression and activity of CYP2E1 weredownregulated in a rat hepatoma cell line after theadministration of proinflammatory cytokines, leading to a loss of catalytic...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... parts of the protein molecule (e.g. either pro-tonation of a number of side chains, binding of metals to an unfolded state or mutations at specific sites) arekey to amyloid formation. One of the ... unfold-ing of the a-helix from the body of the b-sheet(Fig. 2C).Possible role of domain-swapping in the ‘off-pathwayfolding’ (OFF) modelThe OFF model for amyloid formation was firstdescribed by Pallitto ... whichwould lead to a linear, colloid-like growth of amyloidprotofibrils. Glabe [28] suggested that, instead of selecting oligomers by size, they could be selected by the structural epitopes that become...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... nonamy-loidogenic but cytotoxic [14,18]. In the presence of MPTP, dopamine accelerated the rate of fibrillation,leading to a higher rate constant of aggregation.Because accumulation of the toxic protofibrils ... dopamine–quinoneadducts (because of auto-oxidation of the neurotrans-mitter), especially dopaminochrome, with a-synuclein,inhibited the conversion of the more-toxic a-synucleinprotofibrils to the less-toxic mature ... with MPTP, therate of formation of the more toxic protofibrils (mea-sured as lag time) was delayed, whereas the rate of conversion of protofibrils to the less toxic fibrils (mea-sured as apparent...
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Từ khóa: tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngbáo cáo khoa học số loài quý hiếm tại vườn quốc gia ba bểtai lieu bao cao thuc tap khoa co khitai lieu bao cao thuc tap tai khoa duoc benh vienchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM