Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc

... remodeling regulates integrin and E-cadherin functionIntegrin sugar chains play important roles in the biological functions of integrins A growing body of evidence indicates that the presence of the ... site. The C-terminal segmentstraverse the plasma membrane and mediate interactionswith the cytoskeleton and with signaling molecules. On the basis of extensive searches of the human and mousegenomic ... Glycosylation reactions catalyzed by the glycosyltransferases GnT-III and GnT-V,as well as by Fut8, and their biological func-tions. Biological functions of branched N-glycans Y. Zhao et al.1940...

Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf

... understand the biological signiﬁcance of the differ-ence in TnI–TnC interactions, we compared the ability of TnC to neutralize the inhibitory effects of the C-ter-minal fragments in the presence and ... ATnI130)252, and ATnI232)292did not migrate into the gels, while free ATnI-52K and ATnI1)128exhibited a band near the origin and at the middle of the gel, respectively. The bands corresponding to the ... immediately.Measurements of Mg2+-ATPase activity The inhibition of actomyosin-tropomyosin Mg2+-ATPaseby the TnI-fragment and the release of the inhibition byTnC were measured in the presence of 0.05 mgÆmL)1(1.2...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... the condensation and fragmentation of theirnuclei. The percentage of apoptotic cells was calculated as the number of apoptotic cells divided by the total number of cells counted. A minimum of ... lost.Taken together, our results demonstrate an impor-tant relationship among the regulation of nucleo-lin ⁄ C23, the activation of caspase-3 and the induction of apoptosis under the setting of oxidative ... normal and cancerous cells [9], and ubiquitously distributed in the nucleolus, nucleus and cytoplasm of the cell, aswell as at the cell surface [10]. Nucleolin ⁄ C23 regulatesmany aspects of DNA and...

Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf

... the role of estrogen receptors in muscle glucose metabolism is unknown.Therefore, we investigated the expression of the two estrogenreceptors, ERa and ERb and their inﬂuence on regulation of GLUT4, ... rhythyms as their bases. The observables of the culture pro-vide us with a unique insight into the temporal organization of the living state in every cell and at all times.Lloyd D. and Murray ... expression cycles of BMAL1 and CLOCK, the two positive limb members of the molecular oscillators, by periodically repressing the transcription of these genes. In addition, REV-ERBalpha governs the circadianexpression...

Tài liệu Báo cáo khoa học: "Unsupervised Search for The Optimal Segmentation for Statistical Machine Translation" doc

... (2004) and in the scheme“EN” of Habash and Sadat (2006). In Lee (2004), the goal is to match the lexical granularities of the two languages by starting with a ﬁne-grained seg-mentation of the ... occurrence of twophrase pairs in a Turkish-English parallel corpus and the two hypothesized sets of segmentationsfor the Turkish phrases as in Table 1. Without ac-cess to the English side of the ... (#fj) and (#ei) denote the number of occur-rences of fjin sf and eiin se, respectively.Let fkdenote the word hypothesized to be seg-mented. Let the resulting two sub-words be fp and fq,...

Tài liệu Báo cáo khoa học: "Event Matching Using the Transitive Closure of Dependency Relations" pdf

... the dependency relation of the event and that of the de-pendency relation of the sentence. Our aim was toachieve a balance between the speciﬁcity of depen-dency paths and the generality of dependency pairs.In ... Ee and Es, the descendant -of relation of the event descrip-tion e and the sentence s, respectively. We use the following, two-tiered strategy.Let de, dsbe elements of Ee and Es, ... returns true if the morph of the descendant of deis the same as the morph of the descendant of ds, or if both descendants havecanonical mentions with an exact string match; the 3We remove...

Tài liệu Báo cáo khoa học: "Archivus: A multimodal system for multimedia meeting browsing and retrieval" doc

... subset of the available modalities, e.g. voice and pen, and then the full set of modalities. By giving the users dif-ferent subsets in the ﬁrst part, we can compare if the enforcement of certain ... On the other hand,they can freely formulate queries relating to the information they are looking for, e.g. “Did theydecide to put a sofa in the lounge?”. Commandsare interface speciﬁc rather ... combination with other modali-ties, explaining in each step the consequences of the user’s actions on the system. The drawback of this approach is that the user may be biased by the examples and continue...

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... and 482) and one Thr residue (amino acid 487) were well conservedin the KIND2 of v-KIND in all species analyzed,although not in the other KINDs. To investigate the possible involvement of these ... downstream of v-KIND overexpression [12])enhances the activity of MAP2 to bind to microtubules and promote their assembly [18], and that the inhibition of JNK1 (such as downstream of v-KIND knockdown[12]) ... structure of MAP2 and the alignment of v-KIND-binding core (BD) region of MAP2 CD2domain (702–744 aa) in human, mouse and GallusThis supplementary material can be found in the online version of this...

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... birds, mammals and corals is the dmrt genefamily [5]. The prototype members of this group of factors are the Drosophila doublesex (dsx) and Caenor-habditis mab-3 genes. The Dmrt group of molecules ... gene is the product of a gene duplication of the autosomal dmrt1agene and was designated dmrt1bY [8] or Dmy [9]. Itwas shown to be the only functional gene in the wholeY-speciﬁc region of the ... dmrt1bY has all the features of the master regula-tor of testicular differentiation in medaka (see [13] forreview) and because of the discovery of sex-chromo-some-linked dmrt1s in other vertebrates...

Tài liệu Báo cáo khoa học: RMI1 deﬁciency in mice protects from diet and genetic-induced obesity pptx

... expression in the fat and liver isassociated with development of obesity.RMI1 is the component of the BLM helicase com-plex that maintains complex stability and aids in the maintenance of genome ... the RMI1-deﬁcient mice under normal conditions, except the reduced body weight and lower fasting glucose. Of note is the fact that the deﬁcient mice showed a rate of weight gain and amount of ... heterotrimeric G proteins [28].Given the disparity of these reports, elucidation of E2F8’s functions and contribution to the regulation of cell proliferation will require further experiments.Increased...

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