Tài liệu Báo cáo khoa học: The elusive intermediate on the folding pathway of the prion protein pptx

... LP2. The second major location of p25a was in the cytosolic S3 fraction, and only minor amounts of p25a were pres- ent in the other fractions. The partial co-fractionation was confirmed by confocal ... mice [28]. The instability of DA at the neutral pH of the cytosol causes the forma- tion of toxic aminochromes, and these species are not formed when DA is protonated a...

Ngày tải lên: 14/02/2014, 21:20

... represents the range of possible conformations that may exist in solution. Consistent with the conformational change hypothe- sis, Southhall et al. [26] observed that addition of other components of the ... (green) bound to the central opening of WDR5 (PDB code 3EG6). The position of the conserved Arg 3765 is indicated. On the left, a stick representation is used to...

Ngày tải lên: 16/02/2014, 14:20

... in the AD brain. There remains no clear con- sensus on the role of GIF in the pathogenesis of AD, and therefore we will briefly review some of the current thoughts on the role of GIF in AD. There ... outgrowth in response to the insult. As the condition progresses, perturbation to the interaction between neurons and glial cells may reduce GIF synthesis. Therefore, c...

Ngày tải lên: 16/02/2014, 15:20

... interesting new information on the role of this adaptor protein. The endosomal colocalization and ⁄ or cointernaliza- tion of the activated IR and Grb14 raises the question as to whether Grb14 could, ... association of the EGF receptor with Grb7, as previously documented [36]. Whether the membrane translocation of Grb14 induced by EGF involves the direct interaction...

Ngày tải lên: 18/02/2014, 18:20

... expressing it as the fraction of hydrolyzed (Met1)-ONC (M23L). Figure 2 shows the results of the characterization of the hydrolysis reaction as a function of guanidinium chloride concentration and pH. ... (M23L), once the optimal hydrolysis conditions had been estab- lished, we focused our attention on the cyclization reaction. To evaluate the contribution of both pH...

Ngày tải lên: 19/02/2014, 12:20

... directly. Nevertheless, this assay was near the limit of detection for this interaction, as successive dilution of the probe soon led to loss of sig- nal. The low yields of the AP probe and of nucleolin, together ... shown). Further perturbation experiments were carried out using the protein lactoferrin. Lactoferrin, an iron- binding protein of the transferrin fami...

Ngày tải lên: 19/02/2014, 05:20

... replication and repair. DNA replication is tightly controlled to avoid the introduction of muta- tions into the growing DNA chain. One level of con- trol is the balanced supply of deoxyribonucleoside triphosphates ... affect the metabolism of the target cells in more ways than just the therapeutic purpose of the introduced gene. The normal function of nucleoside ki...

Ngày tải lên: 20/02/2014, 01:20

... relates the reading context vocabulary to the discovered themes. Finally, the V-matrix relates the original sentences to each of the themes. The point of the SVD analysis is to discover these themes ... assumption about the nature of the reading con- text. Instead of taking the anchor text as an indicator of the user’s information need, it assumes that the to...

Ngày tải lên: 20/02/2014, 09:20

... separately for the beginning of the first (left) and end of the sec- ond (right) phrases of the candidate fact. For gen- erality, the computation relies only on the part- of- speech tags of the current ... distinguish the quality of extraction patterns based, for instance, only on the percent- age of the seed set that they extract. The second reason is t...

Ngày tải lên: 20/02/2014, 12:20

... the pen. In the remote control version, the recog- nizer can also be activated using a button on the remote control. The main section of the search display (Figure 2) contains two panels. The ... report results for the wireless microphone only. Analysis of the other microphone conditions is ongoing. control and then the tablet. The scenario set as- signed to ea...

Ngày tải lên: 20/02/2014, 12:20