Tài liệu Báo cáo khoa học: a-Methylacyl-CoA racemase – an ‘obscure’ metabolic enzyme takes centre stage pptx

... human and mycobacterial enzymes, or it may be that the S52P human mutant is significantly active and that racemase deficiency results from some other mechanism, e.g. reduced transcription or transla- tion, ... cancer M. D. Lloyd et al. 1102 FEBS Journal 275 (2008) 108 9–1 102 ª 2008 The Authors Journal compilation ª 2008 FEBS REVIEW ARTICLE a-Methylacyl-CoA racemase – an ‘obscur...

Ngày tải lên: 18/02/2014, 17:20

Ngày tải lên: 18/02/2014, 03:20

... Biochem Bio- phys Res Commun 259, 1 5–2 0. 23 Mieusset R, Bujan L, Mansat A, Pontonnier F & Grandjean H (1987) Hyperthermia and human sper- matogenesis: enhancement of the inhibitory effect obtained ... heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J 21, 516 4–5 172. 36 Yan LJ, Rajasekaran NS, Sathyanara...

Ngày tải lên: 18/02/2014, 04:20

... Stability and stabilization of the constrained runs schemes for equation-free projection to a slow manifold. Submitted. 33 Gorban AN & Karlin IV (2005) Invariant Manifolds for Physical and Chemical ... Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-state Enzyme Systems. Wiley, New York, NY. 38 Calder MS & Siegel D (2008) Properties of the Michael- is–Ment...

Ngày tải lên: 18/02/2014, 06:20

... example, EGCG) affect mem- brane raft composition, on the one hand [91,17 2–1 78] and the DNA-methylation status [2 6–2 8] of many genes (e.g. FAS and CLU), on the other hand. EGCG can bind to GpC-rich regions ... occupancy of hypermethylated promoter CpG-islands of tumor suppressor genes in human cancer. Cancer Res 66, 834 2–8 346. 10 Szyf M, McGowan P & Meaney MJ (2008) The social...

Ngày tải lên: 18/02/2014, 14:20

... phosphatases present in mamma- lian cells, PP1 and PP2A, with IC 50 values of 0.2 and 20 nm for PP2Ac and PP1c inhibition, respectively [ 5–7 ]. Being hydrophobic, OA can enter cells, and it has been shown ... of OA and analogs. C. Vale and L. M. Botana DSPs and the cytoskeleton FEBS Journal 275 (2008) 606 0–6 066 ª 2008 The Authors Journal compilation ª 2008 FEBS 6061 Diarrheic shellfish...

Ngày tải lên: 18/02/2014, 14:20

... Mechanisms of cancer chemoprevention by curcumin. Proc Natl Sci Counc Repub China B 25, 5 9–6 6. 6 Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN & Kuttan R (1995) Anti-tumor and antioxidant activity ... pre-Malignant lesions. Anticancer Res 21, 289 5–2 900. 9 Aggarwal BB, Kumar A & Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23...

Ngày tải lên: 19/02/2014, 05:20

... macroscopic methods [3 8–4 1], finite difference Poisson–Boltzmann (FDPB)-based methods [2 0–2 2,42], FDPB and molecular dynamics [4 3–4 5], FDPB and molecular mechanics [25,46,47] and Warshel’s microscopic ... is valuable. Acknowledgements The author thanks Barry Honig for many inspirational discussions and for the support during the work. We thank Trevor Siggers and Therese Mitros for...

Ngày tải lên: 19/02/2014, 12:20

... Science, Japan Advanced Institute of Science and Technology (JAIST), Tatsunokuchi, Japan; 2 Innovation plaza Ishikawa, Japan Science and Technology Agency (JST), Tatsunokuchi, Japan; 3 Department ... ducation, Science, Sports and Culture of Japan (14350433, 14045229) and The Japan S ecurities Scholarship Foundation. References 1. Chiti, F., Calamai, M., Taddei, N., Stefani, M., Ramponi, G. &a...

Ngày tải lên: 19/02/2014, 16:20

... frog- chi(human:sig), eel-chi(human:sig) and T. scyllia-chi(hu- man:sig), were prepared in the same manner. Four other mutants including two substitution mutants, human- sub(Cys101Ala/Cys104Thr) and H. ... specific antibodies against the mammalian (human), amphibian (frog), avian (hen), reptilian (snake) and Osteichthyes ( carp) enzymes we re tested for cross- inhibition of activity, all five a...

Ngày tải lên: 19/02/2014, 16:20