Tài liệu Báo cáo khoa học: Applications of diagonal chromatography for proteomewide characterization of protein modiﬁcations and activity-based analyses doc

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

... the identiﬁcation and characterization of a-conotoxins with selectivity for neur-onal nAChR subtypes and provides examples of their use indeﬁning the compositions and function of neuronal nAChRsubtypes ... domain of each subunit contri-butes to the formation of the hydrophilic pore. ACh binding protein has structural and functional homology to the extracellular ligandbinding domain of the nAChR, and ... characteriza-tion of native receptors. A thorough comparison and characterization of various a-conotoxins in differentsystems is therefore essential to prove the utility of theoocyte system and the validity...

Tài liệu Báo cáo khoa học: "Phrase-Based Backoff Models for Machine Translation of Highly Inﬂected Languages" docx

... backoff models for combining in-domain and 42out -of- domain data for the purpose of bootstrap-ping a part -of- speech tagger for Chinese, outper-forming standard methods such as EM.4 Backoff ... morespeciﬁc form (i.e. a form closer to the full wordform) is chosen before a more general form (i.e. aform that has undergone morphological process-ing). The procedure is shown in Figure 1 and canbe ... consist of 2000 sentences each. In orderto study the effect of varying amounts of trainingdata we created several training partitions consist-ing of random selections of a subset of the fulltraining...

Tài liệu Báo cáo khoa học: Applications of diagonal chromatography for proteomewide characterization of protein modiﬁcations and activity-based analyses doc

... compilation ª 2007 FEBS 6289MINIREVIEW Applications of diagonal chromatography for proteome-wide characterization of protein modiﬁcations and activity-based analyses Kris Gevaert1,2, Francis ... cover the entire genetic information of several species. This information is now available for aKeywords activity-based probe; ATP-binding proteins;COFRADIC; diagonal chromatography; N-terminal ... FSBA COFRADIC. The structures of ATP and its reactive homolog FSBA areshown in (A) and (B), respectively. TheCOFRADIC reaction sorting for SBA-labeledpeptides is shown in (C).COFRADIC and protein...

Tài liệu Báo cáo khoa học: "Applications of the Theory of Clumps" pptx

... number of occurrences of P1, N2 the number of occurrences of P2, N3 of P3 and so on, and we have O1 and O2 in our example, possessing P1, P2 and P5, and P2, P3 and P5 ... 1951. APPLICATIONS OF THE THEORY OF CLUMPS 127 [Mechanical Translation and Computational Linguistics, vol.8, nos.3 and 4, June and October 1965] Applications of the Theory of Clumps* ... code for our docu- ments by taking the list of keywords for each docu- ment, and replacing it by the list of clusters in which these terms occur. We will thus obtain a cluster list for each document....

Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

... concept for learners of various alphabetic languages (Jared et al., 1990; Ziegler and Goswami, 2005) and of Chi-nese, e.g., (Lee et al., 2005), and is important for both young readers (Ho and ... letters denote the basic elements of Chinese char-acters. For instance, “WG” stands for “田土”, which are the upper and the lower parts of “里”, “WL” stands for “田中”, which could be used to rebuild ... and 6) and (2) speed level: the duration between the monsters’ popping up and going down. The characters for lower, middle, and upper classes vary in terms of frequency and complexity of the...

Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx

... oxidativePPP accounts for at most 44% of the NADPH and 22% of totalreductant needed for fatty acidsynthesisStoich ss, ﬁtEXCEL NG Single time point of metabolites measuredby GC-MS and NMRSchwender ... a key role and allosteric inhibition of PFL and altered pﬂ gene expression areimportant in the regulation of the shiftODE sim, ﬁt NG NG Time series of proteinsmeasured by ELISA and assay kits; ... wellwith respect to the formation of minor compounds involved in winecomplexity and aroma. Therefore,the model also proves useful for exploring the effects of genetic modiﬁcations on fermentationproﬁlesODE...

Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... p25a and DAT (datanot shown). A series of protocols and antibodies weretested for co-immunoprecipitating p25a with DAT and DAT with p25a, and various antibodies were tested for precipitation of ... collected and centrifuged for 15 min at 12 000 g, yielding S2 and P2.P2 was washed by resuspension in 8.5 mL of homogeniza-tion buffer, and re-centrifuged for 15 min at 10 200 g,yielding P2¢ and ... [19], and NMRspectroscopic data of p25a homologs from mice,Caenorhabditis elegans and humans [20–22] demon-strate a folded central core and unfolded N- and C-ter-minal extensions of  45 and...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... experiment 2 for hexoses (black) and sucrose (grey). Doc. S1a. Model structure of C24. Doc. S1b. sbml format of model structure of C24. Doc. S2a. Model structure of Rsch. Doc. S2b. sbml format of model ... control of each assay wasboiled for 3 min after addition of enzyme extract. Reac-tions were incubated for 60 min at 30 and 4 °C, and stopped by boiling for 3 min; the concentration of glucosewas ... assessment of the trajec-tory of interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of theaccessions...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... peptide from the Win motif of MLL1bound to the WD40 repeat protein, WDR5 [24,25] and the C-terminal SET domain in the presence and absence of histone peptides and the cofactor product,S-adenosyl-homocysteine ... Positions of E665 and E555 of the CBP–KIX domain, and residues K291 and R294 of the c-Myb transactivation domain are indicated. (C) TheCBP–KIX:cMyb:MLL1 TAD ternary complex (drawn form PDB code: ... TAD is shown in green and the colors for the CBP–KIX:cMyb are as in (B). Upon formation of the ternary complex, residues E665 and E666 of the CBP–KIX domain become ordered and interact with the...

Tài liệu Báo cáo khoa học: Bacitracin is not a speciﬁc inhibitor of protein disulﬁde isomerase pptx

... speciﬁc inhibitor of protein disulﬁdeisomeraseAnna-Riikka Karala and Lloyd W. RuddockBiocenter Oulu and Department of Biochemistry, University of Oulu, FinlandIntroduction Protein disulﬁde ... Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein- disulﬁde isomerase withA R. Karala and L. W. Ruddock Bacitracin is not speciﬁc for PDIFEBS ... and non-native protein- binding site, and is required for isomeri-zation reactions [2–4], whereas the b domain is of unknown function.PDI is one of a family of  20 PDI-like proteinsidentiﬁed...

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