Tài liệu Báo cáo khoa học: The intracellular region of the Notch ligand Jagged-1 gains partial structure upon binding to synthetic membranes docx

... Jagged-1 cytoplasmic region M. Popovic et al. 5336 FEBS Journal 274 (2007) 5325–5336 ª 2007 The Authors Journal compilation ª 2007 FEBS The intracellular region of the Notch ligand Jagged-1 gains partial ... 2007 FEBS 5325 intracellular region of the different ligands, apart from the identical PDZ binding motif (ATEV) found at the C-terminus of Delta-...

Ngày tải lên: 18/02/2014, 16:20

... homology region 2 (hr2) of the Hth domain, derepressed it to a similar degree as the full Hth deletion (Fig. 4A). To test whether the inhibitory activity of the Hth domain was specific to the Meis2 AD, ... independently of Pbx, and does not possess the autoinhibitory function of the Hth domain. In summary, our data suggest that one function of the conserved Ht...

Ngày tải lên: 16/02/2014, 15:20

... differences in the mode of binding. The promoter p53R2 seems to be less depen- dent on the stability of the protein, indicating that it either possesses more relaxed binding that tolerates small ... that they comple- ment each other. Other classification techniques Other classification techniques were investigated to evaluate whether they could add improvements to the new...

Ngày tải lên: 18/02/2014, 11:20

... primer extension. The primer exten- sion stop on the CMCT treated RNA (+ lane) indicated the presence of pseudouridine at the particu- lar position when the stop was not present in the con- trol ... obtained with the transition at posi- tions 1915 and 1917. These mutations had an effect on the formation of pseudouridine exclusively at the mutant position and did not affe...

Ngày tải lên: 18/02/2014, 16:20

... and they are likely to have closely similar 3D structures. Inspection of the PpPr model identified a patch of negatively ionisable amino acids on the surface of the enzyme, adjacent to the end of the ... compared to that achieved by location of the full-length extension at the N-terminal end of the polypeptide. The benefit of these alterations at each extre...

Ngày tải lên: 19/02/2014, 00:20

... less sensitive to the pres- ence of the anion. These residues also modulate the conformation of unfol- ded cytochrome c, influencing its spin state and the coordination to the prosthetic group. Abbreviation CT, ... candidate for ligand X (the other likely candidates, i.e. the lysines, are fully proto- nated at pH 2.2) [18]. The heterogeneous character of the A-stat...

Ngày tải lên: 19/02/2014, 05:20

... samples 11–14 correspond to QAE isoforms of nfeAFP, whereas the others correspond to SP iso- forms, and the TH activity of the QAE isoform is higher than that of the SP isoform. Fig. 6. TH activity ... and lowers the energy barrier to allow adsorption of the ‘less active’ isoform; (b) the less active isoform (SP or QAE2) can then adsorb to the ‘open space’ betw...

Ngày tải lên: 19/02/2014, 16:20

... in terms of the number of the enzymes involved, the kinetic mechanisms of the competing enzymes and the number as well as the nature of the allosteric controls. Whether such diversity in the organization ... was of special interest to use the in vitro system to test the effect of AMP on the partition of the flux of Phser under physiological condition...

Ngày tải lên: 20/02/2014, 02:21

... Subtypes of the Part-Whole Relation: Do Not Mix your Seeds Ashwin Ittoo University of Groningen Groningen, The Netherlands r.a.ittoo@rug.nl Gosse Bouma University of Groningen Groningen, The Netherlands g.bouma@rug.nl Abstract An ... initialized fol- lowing the traditional practice of a single set that mixes seeds of the different types. To distinguish between types of...

Ngày tải lên: 20/02/2014, 04:20

... front of the "desk". Intuitively, the closer the "stool" is to the region of space defined by the projection of the desk's dimensions into this space, the more the spatial ... addition to the constraint on the proximity of the LO and RO, projective prepositions place a constraint on the position of the LO relative to a pa...

Ngày tải lên: 20/02/2014, 21:20