... Jagged-1 cytoplasmic region M. Popovic et al.
5336 FEBS Journal 274 (2007) 5325–5336 ª 2007 The Authors Journal compilation ª 2007 FEBS
The intracellular region of the Notch ligand Jagged-1 gains
partial ... 2007 FEBS 5325
intracellular region of the different ligands, apart from
the identical PDZ binding motif (ATEV) found at the
C-terminus of Delta-...
... homology region 2 (hr2) of the Hth
domain, derepressed it to a similar degree as the full
Hth deletion (Fig. 4A). To test whether the inhibitory
activity of the Hth domain was specific to the Meis2
AD, ... independently of Pbx, and does not
possess the autoinhibitory function of the Hth domain.
In summary, our data suggest that one function of
the conserved Ht...
... differences in the mode of
binding. The promoter p53R2 seems to be less depen-
dent on the stability of the protein, indicating that it
either possesses more relaxed binding that tolerates
small ... that they comple-
ment each other.
Other classification techniques
Other classification techniques were investigated to
evaluate whether they could add improvements to the
new...
... primer extension. The primer exten-
sion stop on the CMCT treated RNA (+ lane)
indicated the presence of pseudouridine at the particu-
lar position when the stop was not present in the con-
trol ... obtained with the transition at posi-
tions 1915 and 1917. These mutations had an effect on
the formation of pseudouridine exclusively at the
mutant position and did not affe...
... and they are likely to have closely
similar 3D structures. Inspection of the PpPr model
identified a patch of negatively ionisable amino acids
on the surface of the enzyme, adjacent to the end of
the ... compared
to that achieved by location of the full-length extension
at the N-terminal end of the polypeptide. The benefit of
these alterations at each extre...
... less sensitive to the pres-
ence of the anion. These residues also modulate the conformation of unfol-
ded cytochrome c, influencing its spin state and the coordination to the
prosthetic group.
Abbreviation
CT, ... candidate for ligand X (the
other likely candidates, i.e. the lysines, are fully proto-
nated at pH 2.2) [18].
The heterogeneous character of the A-stat...
... samples 11–14 correspond to QAE isoforms
of nfeAFP, whereas the others correspond to SP iso-
forms, and the TH activity of the QAE isoform is
higher than that of the SP isoform.
Fig. 6. TH activity ... and lowers the energy barrier to
allow adsorption of the ‘less active’ isoform; (b) the
less active isoform (SP or QAE2) can then adsorb to
the ‘open space’ betw...
... in
terms of the number of the enzymes involved, the kinetic
mechanisms of the competing enzymes and the number as
well as the nature of the allosteric controls. Whether such
diversity in the organization ... was
of special interest to use the in vitro system to test the effect
of AMP on the partition of the flux of Phser under
physiological condition...
... Subtypes of the Part-Whole Relation: Do Not Mix your
Seeds
Ashwin Ittoo
University of Groningen
Groningen, The Netherlands
r.a.ittoo@rug.nl
Gosse Bouma
University of Groningen
Groningen, The Netherlands
g.bouma@rug.nl
Abstract
An ... initialized fol-
lowing the traditional practice of a single set that
mixes seeds of the different types. To distinguish
between types of...
... front
of the "desk". Intuitively, the closer the "stool" is
to the region of space defined by the projection of
the desk's dimensions into this space, the more the
spatial ... addition to the constraint on the proximity of
the LO and RO, projective prepositions place a
constraint on the position of the LO relative to
a pa...