Tài liệu Báo cáo khoa học: Plasticity of S2–S4 speciﬁcity po

Tài liệu Báo cáo khoa học: Bacitracin is not a speciﬁc inhibitor of protein disulﬁde isomerase pptx

... Effects of bacitracin and other compounds on the relative rate of reduction of the B-chain of bovine insulin. Insulin was reduced at 1mgÆmL )1 in the presence of 10 mM dithiothreitol and 1 mM ... effects of zinc on PDI activity). However, the effects of removal of EDTA and addition of bacitracin appeared to be independent of each other (Fig. 2B), implying that any me...

Ngày tải lên : 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf

... Ku70, histone H1 and 28 k proteins, regardless of the type of damage (Fig. 3A, lanes 7–9). In the aggregation of lin- ear and nicked DNA, and high mobility group box (HMGB)1 and HMGB2 proteins ... nucleosomal units of chromatin in equilibrium of ionic conditions [40,41]. Probably, the extent of the aggregation would be regulated by DNA damage-responsive chromatin factors...

Ngày tải lên : 19/02/2014, 06:20

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Tài liệu Báo cáo khoa học: "A High-Accurate Chinese-English NE Backward Translation System Combining Both Lexical Information and Web Statistics" pdf

... (dream)” and “The Dream of the Red Chamber” Translating by Pho- netic Values for Some Parts and by Meaning for the Others The entire NE is supposed to be trans- lated by its meaning and the ... ,/log/ 1context possible of # while,1 ) ofContext ( Where NCT r and NC i denote the appearing times of the rth context CT r and the candidate C i in the returned snipp...

Ngày tải lên : 20/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Plasticity of laccase generated by homeologous recombination in yeast docx

... lac3 and lac5) and hybrid (lac131, lac232 and lac535) sequences are represented by rectangles of variable lengths. Recombinant junctions are indicated by vertical bars. (B) Representation of cupredoxin ... oxidizes one micromole of substrate per minute. Kinetic parameter determination and effect of pH Determination of kinetics parameters was undertaken using two substr...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Plasticity of S2–S4 speciﬁcity pockets of executioner caspase-7 revealed by structural and kinetic analysis pdf

... al. Plasticity of caspase-7 speciﬁcity pockets FEBS Journal 274 (2007) 4752–4765 ª 2007 The Authors Journal compilation ª 2007 FEBS 4765 Plasticity of S2–S4 speciﬁcity pockets of executioner caspase-7 ... subsites of caspase-7 and caspase-8 ⁄ IETD. The caspase-7 residues are colored by atom type, whereas those of caspase-8 are shown in green. J. Agniswamy...

Ngày tải lên : 18/02/2014, 16:20

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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... equal concentrations of vector DNA were incubated in the absence and presence of 0.5 m M DA for 24 h and subjected to analysis of viability by the MTT assay. Co-transfection of DAT with empty vector ... Vernier P & Sidhu A (2003) Modulation of dopamine transporter function by a-synuclein is altered by impairment of cell adhesion and by induction of oxidative...

Ngày tải lên : 14/02/2014, 21:20

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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

... roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss the possibility that both could function as molecular targets for the prevention and treatment of obesity ... of ANG- PTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases. We proposed that suppression of ANGPTL2 signaling or enhancement of ANG- PTL6 ⁄ AGF signaling cou...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... [12,16–21]. Because of its large size, full-length MLL1 protein has thus far proven refractory to structural analysis. However, the modular nature of MLL1 has allowed structural analysis of some individual ... chan- nel that divides a pair of acidic lobes, one of which is composed of residues from the SET-I region and the other of residues from the SET-C and post-SET...

Ngày tải lên : 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... secretion of the MT1 and MT2 isoforms by cultured astrocytes has also recently been reported. The secretion of MT1 and MT2 by astrocytes appears to be regulated because the basal levels of protein secretion ... GIF and MT1 and MT2 include a Cys-Pro-Cys-Pro(6–9) motif and Thr5 in the b-domain of GIF and a different amino acid structure in the a-domain [32]. Structural...

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Steﬁn A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc

... stefin A and the different enzymes is the average distance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the reactive site cysteine and histidine ... FEBS held together by the disulfide bond between C108 and C119. Its attachment to the body of the enzyme is sta- bilized by two salt bridges, between H110 and D22...

Ngày tải lên : 18/02/2014, 04:20

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