Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt

... predominant transcript in the adult intestine and in the developing embryo, whereas Mxi1-SRb transcripts predominate in the adult liver and kidney [12]. In our initial description of Mxi1-SRa and ... arising in the REF assay. E1 is from a Myc + Ras + empty vector point, a1 and a2 are from Myc+ Ras+ Mxi1-SRa points, and b1 and b2 are from Myc+ Ras+ Mxi1-SRb...

Ngày tải lên: 18/02/2014, 16:20

... mice have an increased incidence of systemic lupus erythematosus (SLE), with classical findings including the presence of autoreactive antibodies and glomerulonephritis occurring in a DNase I-level-dependent manner; ... previously. Proteins were determined using a protein assay kit (Bio- Rad) with BSA as a standard. SDS/PAGE was performed in 12.5% (w/v) gels according to the method...

Ngày tải lên: 19/02/2014, 16:20

... important in promoting subunit dissocia- tion [27] and also in maintaining the geometry of the active site. The availability of crystal structures of TIMs from 21 sources and the large database of TIM sequences ... chain of the two residues brings the guanidinium plane and the aro- matic ring of F102 into close proximity, with an almost perfectly parallel arrangement of...

Ngày tải lên: 18/02/2014, 11:20

... processed into buforin-I and fixed to the mucous surface of epithelial cells to prevent the entry of bacteria into the epithelial layer and their invasion into the lower parts of the gastro- intestinal ... with those of ciprofloxacin, LL-37 and amp- icillin (an antibiotic acting as an inhibitor of cell wall synthesis) indicated that the inhibitory effect of the potent quinolon...

Ngày tải lên: 18/02/2014, 14:20

... Molecu- lar cloning and cold-inducible gene expression of ferritin H subunit isoforms in rainbow trout cells. J Biol Chem 271, 26908–26913. 13 Tang SJ, Sun KH, Sun GH, Lin G, Lin WW & Chuang MJ ... affecting rates of transcription and ⁄ or transla- tion and ⁄ or mRNA and protein degradation. This represents a quantitative strategy to offset the lack or excess of kinetic en...

Ngày tải lên: 19/02/2014, 02:20

... N-terminal and the C-terminal pair of a-helices of VVA1 can bind to VVA2 independently of each other and thus enable the direct binding by one molecule of VVA1 of two mole- cules of VVA2. This ... oligomerization of VVA2 and thus its binding to simple lipid membranes (Fig. 1B, lanes 1 and 2). Therefore, this investigation of the structural and binding characteristics...

Ngày tải lên: 19/02/2014, 06:20

... rates in the presence of kirromycin The effect of kirromycin on the growth of GRd.tsf was investigated by measuring growth rates of cultures in LB containing various concentrations of kirromycin. ... nucleotide exchange in EF-Tu by increasing the dissociation of GDP and binding of GTP [26]. In addition, the binding of kirromycin and EF-Ts to EF-Tu are mutually excl...

Ngày tải lên: 21/02/2014, 00:20

... 1-acyl-linked phospholipids (mainly PtdCho and PtdIns) was being remodeled into the ether- linked subclasses (1-alkyl-2-AA-GPC and 1-alk-1-enyl-2- AA-GPE). Examination of SA of products indicated ... synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells wit...

Ngày tải lên: 22/02/2014, 07:20

... dopamine treatment, overexpres- sion of a-synuclein significantly affected the levels of four proteins [stathmin 1, glutathione S-transferase (GST)p, Ran 1 binding protein and C1q binding pro- tein], ... suggested to be linked to early stages of PD pathogenesis [26]. Interestingly, in our model, dopamine induces an increase of the actin bundles regulator fascin 1 [27] and discord...

Ngày tải lên: 15/02/2014, 01:20

... leucine degradation and the sku mutant accumulates branched-chain amino acids in haemolymph, this mutant may be useful in the investigation of unique branched-chain amino acid catabolism in insects. Abbreviations ACAD, ... that of the enzyme-containing solution and was expressed as nmols of 2,6-dichloroindophenol reduced per mg of protein per min. The extinction coefficient...

Ngày tải lên: 18/02/2014, 04:20