Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin pptx
Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin pptx
... MINIREVIEW
Marine toxins and the cytoskeleton: pectenotoxins,
unusual macrolides that disrupt actin
Begon
˜
a Espin
˜
a
1
and Juan A. Rubiolo
1,2
1 Departamento de ... the rapid depolymerization
that they induce [31,34]. However, jasplakinolides
induce actin polymerization, stabilizing actin filaments
and actin nucleation [35]. Another group of macrolides,...
Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins pptx
... MINIREVIEW
Marine toxins and the cytoskeleton: okadaic acid
and dinophysistoxins
Carmen Vale and Luis M. Botana
Departamento de Farmacologı
´
a, Facultad de Veterinaria, USC, Lugo, Spain
Introduction
The ... through mechanisms that probably
involve disruption of filamentous actin (F -actin) and ⁄ or hyperphosphoryla-
tion and activation of kinases that stimulate tight...
Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt
... structural, providing the sup-
port needed to maintain the shape and organization of
the cell and the scaffolding for the actions of catalytic
molecules such as motor proteins. Nowadays, the actin
cytoskeleton ... the impor-
tance of the unpolymerized actin pool for the mainte-
nance of the F -actin system, the cellular response
Fig. 3. Response induced by palyt...
Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf
... increase
in the production of the multimers (compare lanes 2
and 5). Experiments to separate the aggregate and the
supernatant (sup.) after 2 h indicated that both input
substrates and the EJ products ... IV
and XRCC4. Their antigens were detectable in nuclear
fraction (NF) (lane 2), but not in DNA affinity- and
Mono Q-fractions that EJ activity are enriched (lanes
3 a...
Tài liệu Báo cáo khoa học: cN-crystallin and the evolution of the bc-crystallin superfamily in vertebrates pdf
... for the b and c crystallin families.
In mouse it seems that cN and cS have distinct pat-
terns of expression in the eye, with cS in the epithe-
lium and secondary fibers of the lens, the cornea and
retinal ... man [8,9]. In the verteb-
rate lens, the b and c crystallins together account for
the majority of the soluble proteins (the other major
family being the...
Tài liệu Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle pptx
... motif, they are both targeted to the nuc-
leus, and they bind to and become activated by DNase
I-treated DNA. Both PARP-2 and PARP-1 can homo-
and heterodimerise, and both are involved in the base
excision ... preferentially to the daughter centri-
ole throughout the cell cycle [20]. An attractive hypo-
thesis is that the presence of both PARP-1 and
PARP-3 at the cen...
Tài liệu Báo cáo khoa học: Dimer asymmetry and the catalytic cycle of alkaline phosphatase from Escherichia coli doc
... lower
affinity for both the substrate and the product. In the course
of the catalytic cycle the conformation of the subunits
alternates between two states in order to enable substrate
binding and product ... to the
Ser102 conformation and the nature of the metal ion bound
to the M3 site [10]. The APaseP
i
structure displays an
increased mobility of the active site...
Tài liệu Báo cáo khoa học: Functional expression and mutational analysis of flavonol synthase from Citrus unshiu pptx
... amount in the solubilized pellet of
the Gly261fiPro mutant (lane 12) was negligible and the band could
be hardly recognized in the soluble Gly68fiPro and Gly261fiPro
mutant extracts (lanes 9 and 11).
Table ... for FHT [9], and the protein
concentration was adjusted to 0.371 mgÆmL
)1
in the sample.
The documented spectra show the accumulation of 10 scans
with 50 nmÆmin
)1...
Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx
... two-binding site model. The IC
50
(the concentration of the competing ligand that inhib-
its 50% of the specific binding of [
125
I]TC-PCSK9) val-
ues for the higher-affinity and lower-affinity sites ... ⁄
states. The K
d
values obtained for the higher-affinity
and lower-affinity binding sites are listed in Table 1.
The high-affinity and the low-affinity sites accounted
for...
Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... to the view that, across the
animal kingdom, the gene-regulatory cascades triggering sexual develop-
ment bear little resemblance to each other. As a result, the common emerg-
ing picture is that ... switching either from first
being males (protandrous) to become female or vice
versa (protogynous). Nevertheless, the majority of tele-
osts are gonochoristic, meaning that they exi...