... reductaseSREBP-2NADPHPyruvateAcetyl-CoACitrateacetyl-CoAOxaloacetateOxaloacetateACLACCHMG-CoAHMG-CoA synthaseCitrateMalonyl-CoAPalmitateMalateMitochondriaFASACCSCDFatty acid ... PK,pyruvate kinase; ME, malic enzyme; ACL,acetyl-CoA lyase; ACC, acetyl-CoA carboxyl-ase; FAS, fatty acid synthase; SCD, stea-royl-CoA desaturase; GPAT, glycerolphosphate acyltransferase; DGAT, ... protective role of fish oil rich in polyunsaturatedfatty acids (PUFAs) against cardiovascular diseases hasbeen long known. In addition to antiplatelet and coagu-lant actions, PUFAs also inhibit lipogenesis...