Tài liệu Báo cáo khoa học: The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide-associated complex Egd2 under stress conditions docx

... Journal compilation ª 2009 FEBS 5297 The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide-associated complex Egd2 under stress conditions Hiroyuki Hiraishi 1, *, ... Rsp5- mediated ubiquitination of Egd2 is independent of Egd1 and Not4 under stress conditions. Degradation pathway of Egd2 ubiquitinated by Rsp...

Ngày tải lên: 18/02/2014, 11:20

... near the N- and C-termini of the linkers: this suggests that a mobile connection with both the catalytic domain and the binding module is required for the function of the nanomachine. Furthermore, ... maximum length of 25 amino acids, the whole structure of larger linkers was built manu- ally on the basis of overlapping results from pep-fold. The second step was t...

Ngày tải lên: 14/02/2014, 18:20

... to the first, ‘three-tiered ring’ model, the scarcity of information with respect to the mode of assembly of the three proteins suggests that it is still early to discard the possibility of the ... function appears to be the only one that is common to all bacteria. In Yer- sinia, the increased synthesis of LcrV triggered by the activation of the system leads to...

Ngày tải lên: 14/02/2014, 22:20

... [13,23,28,30–33]. The genetic evidence for the role of AMPK in the hypothalamus is less clear because the loss of the AMPKa2 subunit in specific hypothalamic cell types resulted in the opposite pheno- type ... entry of fatty acid into mitochon- dria. Thus, the steady-state level of malonyl-CoA in these tissues is determined by the relative activities of ACC and malo...

Ngày tải lên: 14/02/2014, 22:20

... critical step in the activation of mitochondria-dependent apoptosis [12], the assembly of the apoptosome. Upon formation of this complex, caspase-9 acquires the ability to trigger the processing ... decreasing the activity of caspase-3 in the three cell lines. Effect of HSS knockdown on CCCP-induced apoptosis To further elucidate the functional role of HSS in CCCP...

Ngày tải lên: 16/02/2014, 09:20

... concentration of these natural antibi- otics, the resistance of the microbial membrane (i.e. the target of the antimicrobial peptides) in a given ionic environment is the counterpart to effectiveness of ... skin. These individuals have high levels of cathelicidin and higher levels of the enzyme that processes the propeptide into the LL-37 biologically active peptid...

Ngày tải lên: 18/02/2014, 06:20

... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were stained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... complete MATH domain and the N-terminal region of RAP2.4 The use of a truncated version of BPM1 in the Y2H screens demonstrated that the BTB domain is not invol...

Ngày tải lên: 18/02/2014, 06:20

... examined the effect of deletion of the components of the PDZ binding motif on the signal- ing properties of the receptor in Ca 2+ imaging experiments. Truncation of the receptor from the final ... and the sites of expression of ORs are the ciliary structures of the OSNs. Interestingly, we found MUPP1 to be pre- dominantly expressed in the apical compartmen...

Ngày tải lên: 18/02/2014, 13:20

... case of the RNA muta- tions to the SRP complex, the mutated RNA residues are located in a double-stranded region of RNA, and do not interact with the protein [54], yet the disruption of the helix ... approximated by the sum of the probabilities of observing the set intermolecular distances defined in the 3D structure, relative to the likelihood of encounterin...

Ngày tải lên: 18/02/2014, 16:20

... reference, the position of the sugar and of the metal in the crystallo- graphic template 1YOE. The two ligands were modelled in each binding site of SsCU-NH, and then the structure of the resulting complex ... pro- trudes towards the exterior of the tetramer near loop 275–288 of the opposite monomer. Therefore, the binding and adaptation of this portion...

Ngày tải lên: 18/02/2014, 17:20