Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... MINIREVIEW Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor Masabumi Shibuya1,21 Department of Molecular ... EC, endothelial cell; FGF, ﬁbroblast growth factor; HIF, hypoxia-inducible factor; PlGF, placenta growth factor; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor ... VEGF-D, binds and activates thisreceptor, resulting in the proliferation and migration of lymph ECs and lymphangiogenesis [13]. Angiogenesis in brain diseases Brain strokeStroke is induced through:...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf

... main-tenance of BBB, modulate neurovascular coupling and maintain several parts of brain homeostasis. In thisminireview, we focus on the active functions of astro-cytes in regards to brain ... signaling pathways involved in pathﬁnding, growth, migration and differentiation. In fact, a num-ber of factors known in CNS development, includingaxon guidance molecules and neurotrophins, ... system used by proteins, such as insulin, trans-ferrin and leptin, to cross the BBB [13].Molecular basis of brain angiogenesis and barriergenesisHypoxia and the hypoxia-inducible factor systemAs...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx

... MINIREVIEW Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recoveryafter strokeKen Arai, Guang Jin, Deepti Navaratna and Eng H. ... and remodeling. A sys-tematic understanding of these responses may eventu-ally lead us to discover new targets for treating brain injury after stroke.Early neurovascular damage in stroke In ... volume and severity of infarcts and the absolute number of circulating CD34+ and CD133+ cells (both thought to be markers for EPCs)[69]. In clinical stroke patients, an increase in circulat-ing...

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... epidermal growth factor receptor (EGFR) is com-posed of an extracellular ligand-binding domain, atransmembrane domain and an intracellular tyrosinekinase domain. The binding of a ligand to the extracel-lular ... phos-phorylating the retinoblastoma (RB) protein. Activa-tion of cyclin–CDK complexes is counterbalanced byCDK inhibitors, including those of the kinase inhibitorproteins (KIP) family and the INK4 ... consists of p27KIP1, p21WAF1 ⁄ CIP1 and p57KIP2; and the INK4 family consists of p15INK4b,p16INK4a, p18INK4c and p19INK4d.AG1478, which, like geﬁtinib and erlotinib, acts as aspeciﬁc inhibitor...

Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

... Lewybody inclusions should have a key role in our under-standing of the mechanisms of the disease. We proposethat pathology data will, in most cases, be moreinsightful than clinical data in deﬁning ... destinations.Cells from NPC subjects show a decrease in acidsphingomyelinase activity, leading to the accumulation of sphingomyelin [27]. Because one of the pathwaysfor ceramide recycling ... restlesslegs and lancinating pain are other presentations of thedisorder, which often results in severe distal sensoryloss and mutilating acropathy [32]. Although muta-tions in SPTLC1 cause...

Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc

... domain structure. Schematic of Vrp1p showing the Vrp1p truncations and mutant proteins used in this study and theirvarious known domains: actin-bindingdomains, Hof one trap (HOT) domain, and LBD. ... actin-based endocyticmachinery in yeast. Dev Cell 9, 87–98.15 Sun Y, Martin AC & Drubin DG (2006) Endocyticinternalization in budding yeast requires coordinatedactin nucleation and myosin ... C-terminal actin-binding submod-ule (CABS) that contains a novel G-actin-binding domain, which we call averprolin homology 2 C-terminal (VH2-C) domain; and a second submod-ule comprising the...

Tài liệu Báo cáo khoa học: "The Thesaurus in Syntax and Semantics" docx

... policy of interlingualizing the thesaurus, (that is, of assimilating semantics to syntax) and that of thesaurizing the syntax (that is, of in- cluding syntax within semantics) the linguists ... rigorous separation of the particular from the comparative universal range of validity (in MT terminology, of monolingual from interlingual features), and by their separate handling in the program ... employment of thesauri in machine translation. Limited success has been achieved, in punched- card tests, in improving the idiomatic quality and so the intelligibility of an ini- tially unsatisfactory...

Tài liệu Báo cáo khoa học: How to remain nonfolded and pliable: the linkers in modular a-amylases as a case study ppt

... participatingTable 1. Amino acid frequencies (%) in a-amylase linkers, in a set of globular proteins, in the Swiss-Prot databank and in intrinsicallyunstructured proteins.Aminoacid LinkersaGlobularproteinsbSwiss-ProtcIntrinsicallyunstructuredproteinsbAla ... structure of this domain in recently available sequence and genomedatabanks. Interestingly, this domain was found in some closely related bacterial species, but mainly in nonvertebrate animals, and invariably ... the ring may sterically disfavor extensivebending in this region, which could result in unwantedinteractions between the linker and the binding module. In this respect, 72% of the C-terminal...

Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx

... (solvent B) at a ﬂow rate of 0.3 mLÆmin)1: lin-ear increase from 0% B to 50% within 20 min followed bya linear increase to 95% B in 5 min, holding B for anadditional 5 min. This gradient was ... (solvent B) at a ﬂow rate of 16 mLÆmin)1: lin-ear increase from 0% B to 50% within 50 min followed bya linear increase to 95% B in 5 min, holding B for an addi-tional 5 min. The wavelengths chosen ... l-d-N-hydroxyornithine (l-hOrn), respec-tively, as found in the assembly of enterobactin and coelichelin [6,7]. The C-terminal adenylation domainA4again is predicted to activate l-arginine, displaying60%...

Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf

... uncoupling in hepatocytesleads to PTP opening and cell swelling, an event thatis probably reduced in extent by CsA. CsA speciﬁcallyinhibits PTP opening by binding to cyclophilin D in the matrix and ... swelling of liver and heart mitochondria by cyclosporine is probably causedby the inhibitor binding to mitochondrial-matrix pept-idyl-prolyl cis–trans isomerase and preventing it inter-acting ... of HTC hepatoma cell growth in vitro by hepaticstimulator substance (HSS). Interactions with serum,insulin, glucagon, epidermal growth factor and plateletderived growth factor. Exp Cell Res...

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