Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... MINIREVIEW Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor Masabumi Shibuya 1,2 1 Department of Molecular ... EC, endothelial cell; FGF, fibroblast growth factor; HIF, hypoxia-inducible factor; PlGF, placenta growth factor; VEGF, vascular endothelial growth factor; VEGFR, v...

Ngày tải lên: 18/02/2014, 11:20

... main- tenance of BBB, modulate neurovascular coupling and maintain several parts of brain homeostasis. In this minireview, we focus on the active functions of astro- cytes in regards to brain ... signaling pathways involved in pathfinding, growth, migration and differentiation. In fact, a num- ber of factors known in CNS development, including axon guidance molecules...

Ngày tải lên: 18/02/2014, 11:20

... MINIREVIEW Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke Ken Arai, Guang Jin, Deepti Navaratna and Eng H. ... and remodeling. A sys- tematic understanding of these responses may eventu- ally lead us to discover new targets for treating brain injury after stroke. Early neurovascular damage in...

Ngày tải lên: 18/02/2014, 11:20

... epidermal growth factor receptor (EGFR) is com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The binding of a ligand to the extracel- lular ... phos- phorylating the retinoblastoma (RB) protein. Activa- tion of cyclin–CDK complexes is counterbalanced by CDK inhibitors, including those of the kinase inhibitor...

Ngày tải lên: 16/02/2014, 09:20

... Lewy body inclusions should have a key role in our under- standing of the mechanisms of the disease. We propose that pathology data will, in most cases, be more insightful than clinical data in defining ... destinations. Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27]. Because one of the pathways for c...

Ngày tải lên: 18/02/2014, 14:20

... domain structure. Schematic of Vrp1p showing the Vrp1p truncations and mutant proteins used in this study and their various known domains: actin-binding domains, Hof one trap (HOT) domain, and LBD. ... actin-based endocytic machinery in yeast. Dev Cell 9, 87–98. 15 Sun Y, Martin AC & Drubin DG (2006) Endocytic internalization in budding yeast requires coordinated actin nucle...

Ngày tải lên: 18/02/2014, 16:20

... policy of interlingualizing the thesaurus, (that is, of assimilating semantics to syntax) and that of thesaurizing the syntax (that is, of in- cluding syntax within semantics) the linguists ... rigorous separation of the particular from the comparative universal range of validity (in MT terminology, of monolingual from interlingual features), and by their separate...

Ngày tải lên: 19/02/2014, 19:20

... participating Table 1. Amino acid frequencies (%) in a-amylase linkers, in a set of globular proteins, in the Swiss-Prot databank and in intrinsically unstructured proteins. Amino acid Linkers a Globular proteins b Swiss-Prot c Intrinsically unstructured proteins b Ala ... structure of this domain in recently available sequence and genome databanks. Interestingly, this domai...

Ngày tải lên: 14/02/2014, 18:20

... (solvent B) at a flow rate of 0.3 mLÆmin )1 : lin- ear increase from 0% B to 50% within 20 min followed by a linear increase to 95% B in 5 min, holding B for an additional 5 min. This gradient was ... (solvent B) at a flow rate of 16 mLÆmin )1 : lin- ear increase from 0% B to 50% within 50 min followed by a linear increase to 95% B in 5 min, holding B for an addi- tional 5 min. The wave...

Ngày tải lên: 16/02/2014, 09:20

... uncoupling in hepatocytes leads to PTP opening and cell swelling, an event that is probably reduced in extent by CsA. CsA specifically inhibits PTP opening by binding to cyclophilin D in the matrix and ... swelling of liver and heart mitochondria by cyclosporine is probably caused by the inhibitor binding to mitochondrial-matrix pept- idyl-prolyl cis–trans isomerase and prevent...

Ngày tải lên: 16/02/2014, 09:20