Tài liệu Báo cáo khoa học: Multisite protein phosphorylation – from molecular mechanisms to kinetic models pdf

... protein phosphatase 6 (DUSP6) TpXYp – – PP1 – RVXF FXXRXR – PP2A, PP2C RRA(Sp ⁄ Tp)VA – – Calcineurin (PP2B) – PXIXIT – Tyr phosphatases PTP1B E(Y ⁄ F ⁄ D)Yp RDXYXTDYYpR – SHP2 YpASI YpIDL – SH2 domain Amino ... RXRXX(S ⁄ T )– – Protein kinase C (PKC) (S ⁄ T)X(K ⁄ R) – – Tyr kinases EGF receptor kinase X(D ⁄ E)YX– – Abl tyrosine kinase (I...

Ngày tải lên: 18/02/2014, 08:20

... (history length = 1) to a unigram state, n − k = 2 − 0 = 2, so we set the backoff weight to 2Φ, − log α h ) for some Φ > 0. In order to combine the model with another au- tomaton or transducer, ... composing with other models, e.g., when combining a language model with a pronunciation lexicon as in widely- used FST approaches to speech recognition (Mohri et al., 2002). Moving fr...

Ngày tải lên: 20/02/2014, 04:20

... Conference Short Papers, pages 17 7–1 80, Suntec, Singapore, 4 August 2009. c 2009 ACL and AFNLP Mining User Reviews: from Specification to Summarization Xinfan Meng Key Laboratory of Computational Linguistics (Peking ... features. 1 Introduction Review mining and summarization aims to extract users’ opinions towards specific products from reviews and provide an easy -to- understand...

Ngày tải lên: 20/02/2014, 09:20

... systems to impose few restrictions on tasks and vocabulary. To solve these problems, it is essential to develop automatic adaptation techniques. Extraction and normalization of. (adaptation to) ... acoustic models, vocabularies of several thousand or several ten thousand entries, and stochastic language models such as bigrams and trigrams. Such methods have 11 been applie...

Ngày tải lên: 20/02/2014, 18:20

... according to the following equation: B z ¼ B i À l j r j where B z is the normalized B factor, B i is the B factor of atom i, l j is the mean B factor (excluding water molecules and peptide atoms) ... 12 1–1 31. 9 Suh KS, Mutoh M, Gerdes M & Yuspa SH (2005) CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy. J Invest Dermatol Symp Proc...

Ngày tải lên: 14/02/2014, 19:20

... soluble protein 12 2–2 28 mPrP(12 2–2 28) No expression data f 12 2–2 30 mPrP(12 2–2 30) No expression data f 12 7–2 28 mPrP(12 7–2 28) No expression data f 12 7–2 30 mPrP(12 7–2 30) No expression data f 2 3–1 44 ... mPrP(12 1–2 31) was purified to homogeneity by anion exchange chromatog- raphy, hydrophobic chromatography, and gel filtration, with yields of 5–1 0 mg of...

Ngày tải lên: 18/02/2014, 08:20

... is thought to be involved in the acetylation of histones and alteration of chromatin structure. A recent study revealed that the activator-recruited co-factor (ARC)–mediator coactivator complex, ... of the ARC–mediator coactivator complex [14]. How SREBPs recruit both of these coactivators on target genes remains unclear. The peroxisome proliferator-activated receptor-c coactivator-1 (PGC-1...

Ngày tải lên: 18/02/2014, 13:20

... inhibitors. HCT116 p53 + ⁄ + cells were transfected with the Flag–s-DAPK-1 vector for 24 h and trea- ted with the indicated protease inhibitors 6 h prior to harvesting. The Flag–s-DAPK-1 protein ... necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. J Biol Chem 277, 4698 0–4 6986. 5 Gozuacik D & Kimchi A (2006) DAPk protein family and cancer. Autophagy 2,...

Ngày tải lên: 18/02/2014, 17:20

... 169, 84 7–8 55. 21 Ruiz-Ruiz C & Lo ´ pez-Rivas A (2002) Mitochondria- dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis ... transcription factor interferon regulatory factor-1. J Biol Chem 279, 1971 2–1 9720. I. W. Jeffrey et al. Control of protein synthesis by IFNa and TRAIL FEBS Journal 273 (2006) 369 8–...

Ngày tải lên: 19/02/2014, 06:20

... homology to various proteins of unknown function. Biofactors 4, 17 7–1 80. 9. McGonigle, S., Dalton, J.P. & James, E.R. (1998) Peroxidoxins: a new antioxidant family. Parasitol. Today 14, 13 9–1 45. 10. ... our laboratories. Heme is the prosthetic group of several proteins and enzymes (myo- globin, cytochrome c, cytochrome P450, ubiquinol-cyto- chrome c reductase, cytochrome c oxida...

Ngày tải lên: 20/02/2014, 23:20