Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

... FEBS MINIREVIEW Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity Constance Auvynet 1,2, * and Yvonne Rosenstein 1 1 Instituto de Biotecnologia, ... [13]. Cathelicidins kill Gram-positive and Gram-negative bacteria and Trypanosoma cruzi. Similar to defensins, cathelicidins participate...

Ngày tải lên: 18/02/2014, 06:20

... [K6,8,9]-indolicidin and [K6,8,9,11]-indolicidin bind strongly to DNA in vitro, suggesting inhibition of intracellular functions via inter- ference with DNA ⁄ RNA synthesis. Whether indolicidin uses ... rather than RNA and protein, and that inhibi- tion of DNA synthesis causes E. coli filamentation and contributes to the antimicrobial activity of indolicidin [49]. Unlike indolici...

Ngày tải lên: 18/02/2014, 06:20

... for- mation of epithelia in the embryo and the maintenance of the polarized epithelial structure in the adult [2]. As a single-span transmembrane-domain glycoprotein, E-cadherin mediates cell–cell ... link E-cadherin indirectly to the actin cytoskeleton [3]. Through the establishment of the CCC, the initial interaction on the extracellular domain is converted into stab...

Ngày tải lên: 19/02/2014, 05:20

... pro- cessing control as the focus of model definition and by including behaviorially defined con- straints, both normal and pathological. The issues are not whether human brains work in a universal ... study the linguistic results. Finally, to further illustrate the problems encountered in determining the phonetic repre- sentation, examples of the implications of de-...

Ngày tải lên: 21/02/2014, 20:20

... modeling and simulation studies revealed that the CT-extension blocks some of the substrate-binding unprimed subsites including the speci- ficity-determining subsite (S2) of the enzyme and thereby ... Comparative studies based on the high-reso- lution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain. J M...

Ngày tải lên: 14/02/2014, 14:20

... the 5¢-hydroxyl group of thymidine, forming dTMP. Human TK1 is cytosolic and its activity is absent in resting cells, appears in late G 1 , increases in S phase coinciding with the increase in ... and the results are pre- sented in Figs 3 and 4. Only in cases where TK1 was incubated prior to the assay with the compounds pro- ducing the dimer, i.e. AMP (Fig. 3F)...

Ngày tải lên: 18/02/2014, 12:20

... present in the PDZ binding motifs of other membrane proteins [17]. We also found interac- tion of PDZ domains 1 + 2 with ORs showing no classical PDZ binding motifs, indicating that the understanding ... including clustering, targeting and routing of their binding partners [13–15]. PDZ target specificity is usually dependent on the extreme carboxyl-terminal amino acid sequence of th...

Ngày tải lên: 18/02/2014, 13:20

... nhiệm vụ của công tác trắc địa là đảm bảo khi thi công đào hầm phải đúng theo thiết kế cả về mặt bằng và độ cao. Bài báo này trình bày phương pháp kiểm tra, từ đó đưa ra nhận xét về khả năng ... tử có độ chính xác cao là phương pháp tối ưu và có độ chính xác tin cậy, đáp ứng được các đòi hỏi về tiến độ xây dựng, về kinh tế có chi phí thấp và đặc biệt phương pháp này phù hợp khi thi ......

Ngày tải lên: 18/02/2014, 13:20

... ubiquinone-deficient strains and in the cyc1 mutant by measuring mRNA levels of stress-inducible genes and the phosphorylation level of the Spc1 MAP kinase. Induction of ctt1, encoding catalase, and ... necessary for the penultimate step in ubiquinone biosynthesis, from the observation that the deletion mutant accumulated the ubiquinone precursor demethoxyubiquinone-10...

Ngày tải lên: 18/02/2014, 14:20

... extracted the protein coordinates and the four nucleotides bound at the center of the domain (for structures containing more than one RNA-binding domain, the structure was divided into two independent ... and do not interact with the protein [54], yet the disruption of the helix clearly affects the binding energy. The effect of these changes in RNA conformation can...

Ngày tải lên: 18/02/2014, 16:20