Tài liệu Báo cáo khoa học: Disulfide bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins ppt

... occurring disulfide bridge on liver BABP ligand-binding properties and backbone dynamics have been investigated by NMR. Interestingly, the disulfide bridge does not modify the protein- binding stoichiometry, ... glycochenodeoxycholic acid; I-BABP, human ileal bile acid-binding protein; iLBP, intracellular lipid-binding protein; L-BABP, chicken liver bile acid-binding prote...

Ngày tải lên: 18/02/2014, 06:20

... Arg522 (NH1) coordinates the chloride ion in tACE]. Arg514 in ACE2 is displaced relative to Arg522 in ACE and is somewhat closer to the zinc-binding site. The CL2 binding site is in close proximity ... contains the zinc-bind- ing site, which faces into the deep cleft formed by the two subdomains connected at the base of the cleft. The hinge-bending motion observed upon inhibitor b...

Ngày tải lên: 20/02/2014, 01:20

... 2010. Learning phrase-based spelling error models from clickthrough data. In Proceedings of ACL. K. Wang and Z. Ming and T-S. Chua. 2009. A syntactic tree matching approach to finding similar questions in community-based ... these existing approaches are considered to be context in- dependent in that they do not take into account any contextual information in modeling word translatio...

Ngày tải lên: 20/02/2014, 04:20

... observable. Interestingly, the RMI1 mRNA level increased signifi- cantly in the liver and intra-abdominal fat of the obese phenotype mice; however, that in the skeletal muscle did not increase, and that in ... the Bloom’s syndrome gene helicase complex that maintains genome integrity and activates cell-cycle checkpoint machinery. Interestingly, diet-induced expression of E2F8 mRNA, whi...

Ngày tải lên: 16/02/2014, 09:20

... bd phan cdng chiing va ngay ehinh bd phan cdng chiing ay cung khdng d'n dinh. Dii sao di niia thi edng ehiing ciing dang quyet dinh hay gdp phan quyet dinh sir thanh edng ... tam chia edng ehiing thanh hai loai edng chiing nghe thuat: edng chiing tinh hoa va cdng chiing phd' thdng. Cdng chiing tinh hoa la nhiing ngudi am hie'u nghe thuat, hp dugc...

Ngày tải lên: 18/02/2014, 03:20

... Schiffmann SN (2002) ‘New’ functions for ‘old’ proteins: The role of the calcium- binding proteins calbindin D-28k, calretinin and parval- bumin, in cerebellar physiology. Studies with knockout mice. ... implicated Ca 2+ signaling through calcineurin (CaN) [13] and calmodulin kinase [14] to play an important role. In addition, a recent study indicates an involvement of Ca 2+ signaling...

Ngày tải lên: 19/02/2014, 07:20

... K, Kuroiwa Y et al. (2008) RNA-binding protein TLS is a major nuclear aggregate-interacting protein in hunting- tin exon 1 with expanded polyglutamine-expressing cells. J Biol Chem 283, 6489–6500. 25 ... solid line), in the presence of 100 l M neurotoxin ( • , dotted line), in the presence of 200 l M neurotoxin ( , dotted line) and in the presence of neurotoxin and 50 l M dopamine (h,...

Ngày tải lên: 14/02/2014, 19:20

... uracil moiety binding in the same fashion [38], which could trigger the initial binding of both substrates. In UpG, the binding of the guanine moiety is deterred by exocyclic O 6 . Close inspection ... S2). In both structures, the bound inhibitors span the nucleo- base-binding subsites. Surprisingly, however, the N-acylsulfonamidyl groups point away from the active site (Figs 4 and 5)...

Ngày tải lên: 14/02/2014, 22:20

... having sufficient power are therefore extremely important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining ... time-consuming and greatly in uenced by individual handlers. IntelliCages are automated learning cages where animals carrying transponders are housed in groups and trained in learning...

Ngày tải lên: 16/02/2014, 09:20

... fundamental SET domain in these HMTs is intriguing. In addition, many of the H3K4 HMTs share several domains ⁄ com- ponents, indicating a common mechanism of action. Concluding remarks Studies in several ... proteins in budding and fission yeasts share a high degree of similarity in their SET domains. However, these two proteins exhibit 26% sequence iden- tity overall [69]. The N...

Ngày tải lên: 16/02/2014, 14:20