Tài liệu Báo cáo khoa học: The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase required for heme d1 biosynthesis doc

... FEBS The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl- L-methionine-dependent uroporphyrinogen III methyltransferase required for heme d 1 biosynthesis Sonja Storbeck 1 , Johannes Walther 1 , ... with the two other SUMTs from P. aeruginosa (CysG, CobA; Fig. 1C) that are involved in siroheme and cobalamin bio- synthesis. Therefore, it was proposed tha...

Ngày tải lên: 18/02/2014, 06:20

... near the N- and C-termini of the linkers: this suggests that a mobile connection with both the catalytic domain and the binding module is required for the function of the nanomachine. Furthermore, ... extreme opposites for the dynamics of a polypeptide chain. The unusual abundance of Gly can be explained by the absence of a side chain, allowing dihedral angles not acce...

Ngày tải lên: 14/02/2014, 18:20

... at the tip of the secretion needle and its importance in the formation of the translocon strongly suggests that the hydrophilic translocator could be considered as an assembly platform for the translocation ... although the nature of the cellular signal required and the mecha- nism of its transduction are still a matter of debate [14,15]. The third, major part of the...

Ngày tải lên: 14/02/2014, 22:20

... synthesis is the carboxylation of acetyl-CoA to form malonyl-CoA, catalyzed by ACC – the key reg- ulatory enzyme in the pathway. Malonyl-CoA serves as the basic chain-elongating substrate for the formation of ... transcript. Taken together, these findings provide a compelling argument for the role for malo- nyl-CoA in regulating feeding behavior. The question arises, what d...

Ngày tải lên: 14/02/2014, 22:20

... [29]. Cathelicidins The human cathelicidin gene is located on chromo- some 3 (3p21.3), in close proximity to the genes encod- ing TLR-9 and Myd88 (3p22). Cathelicidins are constitutively synthesized ... epithelial cells. When released into the extracellular milieu, they exert their antimicrobial activity directly by attacking the microbe membrane, and in the intracellular com- par...

Ngày tải lên: 18/02/2014, 06:20

... or before the adipogenic commitment stage and that the IDM-induced genes appear to overcome the inhibitory effects of miR-27. In order to determine whether miR-27 inhibits adi- pogenesis in general ... cells. These observations, nonetheless, suggest the existence of extensive crosstalk or functional over- lap among different miRNA genes. The miR-27 genes appear to inhibit adipogenes...

Ngày tải lên: 18/02/2014, 08:20

... kDa (see Table 1). Therefore, it can be concluded that the nature of the base is insignificant for the tetra- merization effect. The next goal was to determine the role played by the sugar and phosphate ... K m and the tetramer has low K m , and the ratio between the two forms depends on the dThd concentration [24]. According to this model, the simul- taneous presence i...

Ngày tải lên: 18/02/2014, 12:20

... included in the > 20 s section; n = 15 for control, n =27 for RNAi(exon5). (F) Bar chart showing the rise time (10–90%) for siRNA(exon45) transfected Hana3A cells; n = 12 for control, n = 12 for RNAi(exon45). ... examined the effect of deletion of the components of the PDZ binding motif on the signal- ing properties of the receptor in Ca 2+ imaging experiments. Trun...

Ngày tải lên: 18/02/2014, 13:20

... yet the disruption of the helix clearly affects the binding energy. The effect of these changes in RNA conformation cannot be captured by the intermolecular potential function used here. Given these ... mutants for which binding constants are reported in the literature. Then the distance-dependent potential scores for these structures were compared with the known binding c...

Ngày tải lên: 18/02/2014, 16:20

... interruption of the geometry of the recognition helix for either Antp or the TTF-1 HD, the anomalous amide exchange pattern and the NOE connectivity data of the C-terminal portion of helix III had to ... motional frequency of the corresponding or adjacent backbone amide bond vectors, which accounts for the inhomogeneity of the local correlation times. For helix III,...

Ngày tải lên: 18/02/2014, 16:20