Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc

... FEBS Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast Karen van Eunen 1 , Jildau Bouwman 1, *, Alexander ... condition. Time-dependent regulation analysis during the first 4 h If the initial regulation during nitrogen starvation was dominated by unspeci...

Ngày tải lên: 18/02/2014, 06:20

... code for a single protein. Interestingly, during the initial process of identifying the NR family members in the A. aegypti genome, we predicted two isoforms of AaFTZ-F1, differing only in their ... dis- played in AaHNF-4A in hormone-free media that har- bors a complete balance of amino acids suggests the involvement of amino acids in its regulation. This amino acid induced signa...

Ngày tải lên: 18/02/2014, 13:20

... certain in u- enza strains do not agglutinate cRBCs, using specific human-adapted in uenza hemagglutinins as examples. Finally, recent understanding of the role of various glycan structures in high ... fi 3 and a2 fi 8 linked ter- minal sialic acid moieties, leaving intact a2 fi 6 linked sialic acid, and sialidase A [22], which cleaves a2 fi 3, a2 fi 6, and a2 fi 8 linked sialic acids. In...

Ngày tải lên: 14/02/2014, 19:20

... a conserved DNA-binding motif known as the Doublesex- and Mab-3-related (DM) domain. Being a noncanonical cysteine-rich DNA- binding motif, this domain has two highly intertwined finger structures ... chelate one zinc ion each, and binds to the minor groove of the DNA [6]. Dmrts were originally described to play important roles during sex determination in flies and worms by regulating...

Ngày tải lên: 14/02/2014, 19:20

... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, ... proteins. The common denominator in all different MLL rearrangements is disruption of the MLL protein in a region that prevents any subsequent pro- tein–protein interaction between the resu...

Ngày tải lên: 16/02/2014, 14:20

... 2. Zinc and cadmium binding affinities for MTs in Caenor- habditis elegans and other species. Log K binding constants for zinc and cadmium metalloforms of C. elegans MTs were deter- mined and ... relationship for metallothioneins: histidine coordination and unusual cluster composition in a zinc-metallothionein from plants. Proteins 68, 922–935. Supporting information The followin...

Ngày tải lên: 16/02/2014, 15:20

... graft- ing strategy for generating RNA-cleaving activity in a self-cleaving DNAzyme. The DNAzyme with DNA- cleaving and RNA-cleaving activities was constructed by incorporating the catalytic domain ... RNA-cleaving or DNA-cleaving DNAzymes have been obtained by in vitro selection. However, engineering an allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities is very cha...

Ngày tải lên: 16/02/2014, 15:20

... [M(II) 3 - Cys 9 ], including three bridging and six terminal cyste- ines. The C-terminal a-domain (amino acids 31-61) binds four divalent metal ions by 11 deprotonated cysteines in an adamantane-like ... non-cooperative Cd binding [17] More cooperative Cd binding (at pH 7.4) [17] Zn ⁄ Cd–thiolate clusters Cd ⁄ Zn 3 -CysS 9 in b-domain and Cd ⁄ Zn 4 -CysS 11 in a-domain Same connect...

Ngày tải lên: 16/02/2014, 15:20

... FEBS 3759 Introduction C-peptide is derived from most of the proinsulin seg- ment in between the B and A chains of insulin [1] and has an important structural role in the proper folding and disulfide ... effort aiming to understand the physiologically relevant structures and mechanisms involved in this process. Early studies on proinsulin and insulin behavior in solution re...

Ngày tải lên: 18/02/2014, 04:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... before and after birth in mouse brains [122,124]. No HSF4 DNA-binding activity was reported in the developing mouse brain so far. How- ever, Hsf4b is expressed in the adult mouse b...

Ngày tải lên: 18/02/2014, 04:20