Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt

... 2010 FEBS 4149 MINIREVIEW Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression Hiroshi Sakurai and Yasuaki Enoki Department of Clinical Laboratory Science, ... in determining the target genes of each HSF. This minireview focuses on the molecular mechanisms of DNA recognition, chromatin modulation and gene...

Ngày tải lên: 18/02/2014, 04:20

... against the development of RA [61]. The gene copy number variations of CCL3-like 1 (CCL3L1), a nonallelic isoform of CCL3 encoded by different genes and a potent ligand for CCR1 and CCR5, influenced ... joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and de...

Ngày tải lên: 18/02/2014, 18:20

... 0.5–1% of the popu- lation and causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life. Although the patho- genesis of ... PCR amplification of both NS1 and VP genes of B19 DNA in synovial membranes has revealed that the levels of B19 DNA are similar in RA and control synovial membranes...

Ngày tải lên: 18/02/2014, 18:20

... array of events under the control of NF-jB, including cytokine and cyclo- oxygenase-2 expression, osteoclast differentiation and apoptosis, and the impact of these events on the path- ogenesis of ... RA. Expression of MMPs is proposed to be regulated by AP-1, and the upregula- tion of MMPs in the RA synovium correlates with increased DNA- binding activity of AP-1 an...

Ngày tải lên: 18/02/2014, 18:20

... PUF-8, Drosophila and human Pumilio and yeast Puf3 recog- AB CD Fig. 6. Analysis of binding affinity between APUM-2 and the FAS-2 3¢ UTR transcripts with nucleotide substitutions upstream and down- stream of ... that of other well- characterized members of PUF family. These proteins must bind to transcripts in the plant and regulate their translation and ⁄ or turnover. A la...

Ngày tải lên: 18/02/2014, 06:20

... the DNA to mononucleosome size of samples con- sisting of a mixture of hepta-, octa- and nonanucleosomes and half the amount of hexa- and decanucleosomes (6- to 10-mer sample). (A) (a) Nonamer of ... for the fibre stability of chicken erythrocyte chromatin [5,26]. The loss of linker histone causes exposure of the linker DNA to DNase I [27] and leads to shortening...

Ngày tải lên: 18/02/2014, 18:20

... S, Brandts JF & Lin LN (1989) Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Anal Biochem 179, 131–137. H. Fernando et al. Chemokine ligand–receptor ... form and structured in the bound form. Knowledge of the dynamic characteris- tics of both IL-8 and N-domain before and after binding and whether binding is accompanied by r...

Ngày tải lên: 19/02/2014, 05:20

... half-life of % 13 and 33 min, respectively. Substrate specificity analysis An analysis of the substrate specificity for DNA of the enzymes shows that they both cleave plasmid DNA, dsDNA and ssDNA as ... is plotted and the mean values are drawn. AB Fig. 8. Cleavage of plasmid, dsDNA and ssDNA. (A) 14 nM VcEndA incubated at 23 °C for 5 min with plasmid (lane 2), dsDNA (lane 4)...

Ngày tải lên: 19/02/2014, 05:20

... 35 (13%) carry an idi-1 gene, 72(27%)carryanidi-2 gene, 2 carry both an idi-1 and idi-2 gene, and 154 (59%) appear to be devoid of IPP isomerases. Phylogenetic analyses of 102 type II isomerases ... Germany). Cloning and expression of the idi-2 gene from B. subtilis A DNA segment extending from bp position 184 997– 186 043 of the B. subtilis chromosome was amplified by P...

Ngày tải lên: 19/02/2014, 13:20

... Lankelma 1,2 1 Department of Molecular Cell Physiology, Institute of Molecular Cell Biology, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, the Netherlands; 2 Department of Medical Oncology, ... expression of genes involved in cell cycle progression include Elk1, c-fos, c-Jun and c-myc [9,15]. The duration of ERK activation (transient or sustained) determ...

Ngày tải lên: 19/02/2014, 16:20