Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc

... MAPK ERK1 15 37 55 P P P p53 Fig. 1. Regulation of DNA fragmentation by phosphorylation of the MAPK family and mitochondrial proteins. Phosphorylated ERK prevents the activation of caspases and the Bcl-2 family, whereas these ... mitochondria during apoptosis. They induce the permeabilization of the mitochondrial membrane with the release of cytochrome c and the f...

Ngày tải lên: 14/02/2014, 22:20

... (2001) Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15, 1118–1131. 4 Fujimoto M & Nakai A (2010) The heat shock factor family and ... 2010 The Authors Journal compilation ª 2010 FEBS 4139 MINIREVIEW Regulation of the members of the mammalian heat shock factor family Johanna K....

Ngày tải lên: 18/02/2014, 04:20

... 133–138 at the exposed part of the cathepsin B molecule near the occluding loop (Fig. 2C). The location of the epitope indicates that the binding of 2A2 mAb might change the conforma- tion of the loop, ... of 161.8, 28.2 and 13.2 kDa, respectively. The formation of the cathepsin B ⁄ cystatin C complex was seen as a shift of the elution peak of cathepsin B...

Ngày tải lên: 18/02/2014, 11:20

... in the main chain of the subunit, or in the interaction of subunits within the trimer that linked the conformation of residues 120–125 to the position of the active site lip and closure of the ... movement of the lip formed by a helix 2 and b strand 5 [18]. Apparently, movement of the active site lip prevented binding of the C-terminal residues over the...

Ngày tải lên: 18/02/2014, 16:20

... termination of the pr otein s ynthesis. These data a dd to the growing body of information supporting a preponderant role of p38 in the regulation of gene expression at the level of mRNA stability. The ... further establish the specificity of action of Rho GTPases on CTGF/CCN2 expression, we examined the ability of the constitutively active form s of Rho GTP...

Ngày tải lên: 19/02/2014, 16:20

... remained in the pellet independently of the other components and the ionic strength of the mixture. In the presence o f A TP, the amount of bou nd H MM was very similar (average value of 52.5 ± ... solution. On the other hand, the acceleration of the sliding velocity (and the lower number of stops) of thin filaments could be related to a diminution o f the l...

Ngày tải lên: 19/02/2014, 16:20

... PCSK9-S127R, only the upper and lower, respectively, halves of the ranges are shown, to avoid overlap of the error bars. The results are expressed as percentage of control (c.p.m. in the absence of unlabeled ... reduced from 19 to 16 min and the half-time of the slow phase was reduced from 270 to 154 min. In the presence of unlabeled PCSK9- D374Y, the half-time...

Ngày tải lên: 14/02/2014, 14:20

... (grey). Doc. S1a. Model structure of C24. Doc. S1b. sbml format of model structure of C24. Doc. S2a. Model structure of Rsch. Doc. S2b. sbml format of model structure of Rsch. Doc. S3. Documentation ... & Stitt M (1993) Reg- ulation of the expression of rbcs and other photosyn- thetic genes by carbohydrates – a mechanism for the sink regulation of photosynthes...

Ngày tải lên: 14/02/2014, 22:20

... [46]. The similarity in the K m values is attributable to the uracil moiety binding in the same fashion [38], which could trigger the initial binding of both substrates. In UpG, the binding of the guanine ... [42]. The structure of N-acylsulfonamide 7 was refined with full occupancy, except for the alternative conformations observed for the N-acylsulfonamidyl group an...

Ngày tải lên: 14/02/2014, 22:20

... disappearance of the heavier inactive peak. Furthermore, FPLC analysis of the recombinant wild-type cN-II showed the presence of the tetrameric active form irrespective of the pres- ence of effectors. ... determine the value of K 50 for these compounds. Under these experimental conditions, the accu- mulation of radiolabelled inosine (nucleotidase activity) rep- res...

Ngày tải lên: 15/02/2014, 01:20