Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf

... function of the HSF family FEBS Journal 277 (2010) 4112–4125 ª 2010 The Authors Journal compilation ª 2010 FEBS 4125MINIREVIEW The heat shock factor family and adaptation to proteotoxic stress Mitsuaki ... heat shock factor system: Hsf3 and Hsf4. Cell Stress Chap-erones 4, 86–93.9 Pirkkala L, Nykanen P & Sistonen L (2001) Roles of the heat shock transcription factors in regulation of the heat shock ... as heat shock proteins (HSP) [1]. This responseis called the heat shock response, and is a universalmechanism of protection against proteotoxic stress, including heat shock and oxidative stress. ...

Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

... have been proposed for the binding of the SRL to the active site of RTA in which the principal diﬀerence lies in the conformation of the second ÔGÕ in the target GAGA motifin the 28S rRNA substrate. ... betweenRTA and the rRNA backbone in this area might berequired to maintain the tetraloop in the optimumconformation for catalysis. Both the catalytic role ofRTA and its recognition and binding of the ... hexanucleotide is at the bottom left and the target adenineis at the top of each model. The sidechains of RTA are shown in blue. (A) Model 1 has the tetraloop bound in the active site of RTA...

Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc

... (2003) Responses to the proinﬂammatory cyto-kines interleukin-1 and tumor necrosis factor alpha incells derived from rheumatoid synovium and other jointtissues involve nuclear factor kappaB-mediated ... the recognition sites of the NFAT and Ets factors led us to investigate the potential involvement of the epithelialspeciﬁc Ets factor 1 (ESE-1 ⁄ ESX ⁄ ELF3 ⁄ ERT ⁄ JEN) inthis process. This factor is a likely ... cooperation with other transcription factors such as nuclear factor- jB and nuclear factor of activated T cells. Neutralization of COX-2 is the goalof many anti-inﬂammatory drugs. As an activator of COX-2...

Tài liệu Báo cáo khoa học: "The impact of language models and loss functions on repair disﬂuency detection" pptx

... present; and the repair to Denver replaces the reparandum.Shriberg and Stolcke (1998) studied the location and distribution of repairs in the Switchboard cor-pus (Godfrey and Holliman, 1997), the ... identiﬁes and deﬁnesthree distinct parts of a speech disﬂuency, referred to as the reparandum, the interregnum and the re-pair. Consider the following utterance:I want a ﬂightreparandum  to ... as the upper bound on a model using the ﬁrst 25 best anal-yses. We therefore use the top 25 analyses from the noisy channel model in the remainder of this paper and use a reranker to choose the...

Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx

... (1999)Dementia, gliosis and expression of the small heat Y. Sun and T. H. MacRae Small heat shock proteins and diseaseFEBS Journal 272 (2005) 2613–2627 ª 2005 FEBS 2625 shock proteins Hsp27 and [alpha]B-crystallin ... lens and guard against ischemic and reper-fusion injury due to heart attack and stroke. On the other hand, mutatedsHSPs are implicated in diseases such as desmin-related myopathy and theyhave ... opacities,as does the R116C mutation. However, in contrast to R116C aA-crystallin, the R49C variant localizes to the cell nucleus and the cytoplasm, superﬁcially suggestinga relationship to neurodegenerative...

Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efﬁciency doc

... they can increase the amount of available phosphate by interacting together. Additionally,fusing PhyH-DI to a single-domain phytase appears to be an efﬁcient way to improve the activity of the ... pH(6.0–8.0) and at low temperatures (0–35 °C). We focuson the function and relationship of the two singledomains. Additionally, the possibility that fusion of the PhyH N-terminal domain to other single-domain ... incubation and failed to refoldafter 5 min of boiling. The kinetic values for PhyH and PhyH-DII towardsInsP6at 35 °C and 20 °C are given in Table 1. The higherspeciﬁc activity kcat and Vmaxvalues...

Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx

... of the tomato SlPti1 in tobacco causedenhanced HR in leaves when challenged with P. syrin-gae pv tabaci expressing AvrPto [17]. On the otherhand, expression of the tomato SlPti1 cDNA in the rice ... with PTI1-4 fused to the GAL4 DNA-binding domainor the empty vector pBD, with AGC2-2 or AGC2-3 fused to the acti-vation domain or the empty vector pAD. The left-hand side shows the growth of yeast ... indicatedtime points. The mixes were then incubated with [c-32P]-ATP and MBP (10 l g) for 30 min. The top panel shows the kinase assayvisualized by autoradiography and the bottom panel shows the Coo-massie...

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... include a factor named CDF-1, which wasobserved to bind to the CDE ⁄ CHR elements in the Cdc25C and cyclin A promoters [82,83]. However,many attempts by several groups to clone and furthercharacterize ... the E2F transcription factor family [13]. Since the discovery of the ﬁrst three genesregulated by CDE ⁄ CHR tandem sites, many otherimportant cell cycle-regulator genes have been reported to ... furthercharacterize this factor failed. A protein called CHFhas been observed to bind by EMSA to the CHR in the mouse cyclin A promoter. However, also this factor was not further characterized [84].CDE...

Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt

... signalling and resistance to apoptosis through downregulation of tBid, providing furtherdetails on how EGF receptor and proteasome inhibitors can contribute to the induction of apoptosis and the treatment ... [16,17]. The BH3domain-only proteins are a subfamily of the Bcl-2 family involved in the initiation of apoptosis through the mitochondrial pathway. The key event in the mito-chondrial pathway is the ... pathway is the release of proapoptotic fac-tors from the mitochondrial intermembrane space into the cytosol, resulting in the downstream activation of a family of cytosolic cysteine proteases, caspases,...

Tài liệu Báo cáo khoa học: The plasminogen activator inhibitor 2 transcript is destabilized via a multi-component 3¢ UTR localized adenylate and uridylate-rich instability element in an analogous manner to cytokines and oncogenes pdf

... performed to determine the role of the ARE II and ARE IV sites in the binding ofproteins to the ‘extended ARE’. Binding of cytoplas-mic proteins to the ‘extended ARE’ probe was ﬁrstshown to be ... samples and the plates were returned to the incubator for further incubation.In vitro transcription and RNase protection assay and northern hybridizationA cDNA library prepared with 1 lg of total ... not shown) to an extent similar to thatseen previously with the b-globin and the b-globinAREDtranscripts. Moreover, cloning the 108 nucleotide‘extended ARE’ into the BglII site in the b-globin3¢...

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