... above). The functional role of GIF synthesis and secretionin the brainTaken together, the regulation of GIF synthesis byreactive astrocytes, and its subsequent secretion undercertain conditions, ... in the AD brain. There remains no clear con-sensus on the role of GIF in the pathogenesis of AD,and therefore we will briefly review some of the currentthoughts on the role of GIF in AD. There ... outgrowth in response to the insult. As the condition progresses, perturbation to the interaction between neurons and glial cells may reduceGIF synthesis. Therefore, control over the release of neurotrophic...