Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... mechanisms of the individual domains, in the hope, initially, of simplifying the interpretation of the metallation details of the two-domain protein. The results presented here allow successful and ... five of the 11 cysteinyl sulfurs act as bridging ligands between two metal centers, and the remaining six act as terminal ligands by coordinating to a single meta...

Ngày tải lên: 19/02/2014, 00:20

Ngày tải lên: 16/02/2014, 15:20

... role in modulating the stability of the metal–thiolate cluster and conformation of the b-domain by domain–domain interactions, thus altering zinc homeostasis in the brain and in uencing the bioactivity ... current evaluation of the biological function of growth inhibi- tory factor in the injured and neurodegenerative brain . Recently, the pu...

Ngày tải lên: 16/02/2014, 15:20

... located in independent domains (a b-domain for the N-terminal cluster and an a-domain for the C-terminal cluster). In the absence of metals, apo-thionein (apo-T) is predominantly unstruc- tured and ... the recent developments regarding the chemistry of the metal clusters in metal- lothionein-3, in comparison to those in metallothionein-1 and metallothion- ein-2...

Ngày tải lên: 16/02/2014, 15:20

... MINIREVIEW Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain Claire ... discovery of a brain- specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly...

Ngày tải lên: 16/02/2014, 15:20

... near the N- and C-termini of the linkers: this suggests that a mobile connection with both the catalytic domain and the binding module is required for the function of the nanomachine. Furthermore, ... ‘pliable’ [13] and are expected to behave as a spring, allowing the nanomachine (catalytic domain–linker–binding module) to crawl on the substrate surface. The poss...

Ngày tải lên: 14/02/2014, 18:20

... employed for the structural study of the T3SS translocation pore within the eukaryotic membrane. Given the impor- tance of T3SS in the infection and invasion processes of a number of bacteria, these ... by the sug- gestion that pH sensing by Salmonella involves modi- fications in the assembly of the translocon, which affect the pH gradient within the needle,...

Ngày tải lên: 14/02/2014, 22:20

... that the former is closer to a SIM than the latter. Using these plots and having measured the concentration of EIIAÆP, the investigator can read the values of the remaining eight concentrations off the ... ½HPr tot ¼ ~ z 2 þ ~ z 3 þ ~ z 8 þ ~ z 9 ; ½EIIA tot ¼ ~ z 3 þ ~ z 4 þ ~ z 10 þ ~ z 11 ; ½EIICB tot ¼ ~ z 4 þ ~ z 5 þ ~ z 12 þ ~ z 13 ð22Þ Using these, we can express...

Ngày tải lên: 18/02/2014, 06:20

... abnormal in ammation and vascular reactivity in facial skin. These individuals have high levels of cathelicidin and higher levels of the enzyme that processes the propeptide into the LL-37 biologically ... numbers in the locus of b-defensin in chromosome 8. As a result of this deficiency in a-de- fensins and b-defensins, luminal microbes invade the mucosa and...

Ngày tải lên: 18/02/2014, 06:20

... three main classes of PDZ binding motifs, occurring at the C-terminus of the interacting proteins [16]. We scanned the human olfactory receptor repertoire for putative binding motifs and discovered them ... finally examined the effect of deletion of the components of the PDZ binding motif on the signal- ing properties of the receptor in Ca 2+ imaging experiments...

Ngày tải lên: 18/02/2014, 13:20