Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): a unique metalloprotein ppt

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships docx

... including: a pre- served array of 20 cysteine residues; and two domains, each of which wrap around a metal–thiolate cluster Keywords metallothionein (MT); mutation; neuronal growth-inhibitory factor ... the metal–thiolate cluster, and the domain–domain interactions. Abbreviations AD, Alzheimer’s disease; DTNB, 5,5¢-dithiobis-(1-nitrobenzoic acid); GIF, neuronal growth-inhibitory...

Ngày tải lên : 16/02/2014, 15:20

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**Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc**

... S, Saito T, Hosokawa T, Takahashi Y, Numata T & Kurasaki M (2005) Metal binding ability of metallothionein-3 expressed in Escherichia coli. Basic Clin Pharmacol Toxicol 96, 295–301. 36 Karotki ... Palumaa P, Eriste E, Njunkova O, Pokras L, Jornvall H & Sillard R (2002) Brain-speciﬁc metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals ....

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... Kohmura E, Sakaki T, Nonaka M, Yamada K, Yamashita T, Kishiguchi T, Sakaguchi T & Hayakawa T (1997) Expression of growth inhibitory factor mRNA after focal ischemia in rat brain. J Cereb Blood ... impaired. Mol Chem Neuropathol 32, 101–121. 17 Sogawa CA, Asanuma M, Sogawa N, Miyazaki I, Nakanishi T, Furuta H & Ogawa N (2001) Localiza- tion, regulation, and function of metallothionei...

Ngày tải lên : 16/02/2014, 15:20

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Tài liệu Báo cáo khoa học: Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors doc

... Torpedo marmorata ray and availability of selective pharmacological tools like the snake a- neurotoxins. The analysis of both muscle and neuronal subunit sequences reveal a high degree of identity and ... remarkable features. We have generated homology models of several nAChR subtypes [2 7a] , so that we can start to analyse in detail the nAChR pharmacophore that binds a- conotoxins at...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt

... Queensland, Brisbane, QLD, Australia a- Conotoxins that target the neuronal nicotinic acetylcholine receptor have a range of potential therapeutic applica- tions and are valuable probes for examining ... Mutational analyses have also been valuable in elucidating factors important for activity. Table 2 lists the most informative mutations that have been made in a range of a- conotoxi...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism doc

... CT ex 114 aa 208 aa 24 aa BamH 34 aa Start Stop Xho1 N -Pro Protease domain Protease domain CT - ex 380 aa 1 II NP 114 aa 208 aa BamH1 34 aa Start Stop Xho1 SS SS G SSS S N-Pro 356 aa III MSTLFII S ILLFLAS F SYAMDI S TIEYKYDKSS AWRTDEEVKEIYELWLAKHDKVY SG LVEYEKRFEIFKDNLKFIDEH NSENHTYKMGLTPYTDLTNEEFQAIYLGTRSDTIHRLKRTINISERYAYEAGDNLPEQIDWRKKGAVTPVKNQGKCG SCWAFSTVSTVESINQIRTGNLISLSEQQLVDCNKKNHG...

Ngày tải lên : 14/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... (excluding water molecules and peptide atoms) and r j is the standard deviation of B factors. The normalized B factors have a zero mean and unit variance. All atoms that satisfy B z ‡ 4 are treated as ... importin -a nuclear import pathway, provided that CLIC4 can undergo a conforma- tional rearrangement that exposes the NLS in an extended conformation. Database Structural data are avail...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: Kinetics of dextran-independent a-(1 ﬁ 3)-glucan synthesis by Streptococcus sobrinus glucosyltransferase I pdf

... Methyl a- d-glucopyranoside was used as a glucose analog that is not a substrate of hexokinase in a glucose assay system. The data were analyzed on the basis of the Michaelis–Menten equation; the maximum activity ... glucansucrase modulates glucan and oligosaccharide synthesis. Appl Environ Microbiol 66, 1923–1927. 27 Komatsu H, Katayama M, Sawada M, Hirata Y, Mori M, Inoue T, Fukui K,...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: a coupled oscillator-based mechanism in smooth muscle ppt

... Pharmacology, University of Calgary, Alberta, Canada 2 School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, Australia Long-range signaling Biological organs display coordinated ... membrane depolarization activating or advancing the phase of other Ca 2+ stores. The electrical and chemical transduction pathways are as depicted in Fig. 3. The key mechanisms are as follows: (a...

Ngày tải lên : 16/02/2014, 09:20

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