Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt

... suggesting that another factor or other signals are required to fully derepress Meis2d. The Meis2e splice variant retains the Hth domain, but lacks both the HD and the AD. It could therefore interact ... not possess the autoinhibitory function of the Hth domain. In summary, our data suggest that one function of the conserved Hth domain is to inhibit the activity o...

Ngày tải lên: 16/02/2014, 15:20

... (ortho- logue of human RPE65) and retains all of the known key residues for the enzymatic activity of RPE65. Similar to the other RPE-specific RPE65, RPE65c was present in both the membrane and cytosolic ... spans the entire thickness of the inner retina. The Mu ¨ ller cell constitutes an ana- tomical link between the retinal neurones and supports their activities by...

Ngày tải lên: 14/02/2014, 14:20

... handedness, and two of the rings face in the opposite direction in the membrane to the other two, forming the same pattern as in the AFM surface representation of Fig. 2A. By comparison with the ... composition of the c ring from A. woodii The above structural analyses clearly assigned 22 transmembrane helices to the c ring of A. woodii.To unravel the c 1 and c 2...

Ngày tải lên: 18/02/2014, 17:20

... the depletion of the Myc tag only changes the size of the upper band, and that therefore the upper band repre- sents the ‘full-length’ s-DAPK-1. Two s-DAPK-1 deletion mutants, Flag-AO (Anky- rin ... determine the mechanism that underlies the effect of the tail on the membrane-blebbing-promoting ability of s-DAPK-1, the localization and half-lives of the ful...

Ngày tải lên: 18/02/2014, 17:20

... instructions to the Russian readers, which were to use any ingenuity or knowledge of Russian they might have to divine the meaning of the translations. The rankings of the translations by the average ... of the significance of the differences of the rank-ordered means in each column. Any two means embraced within a given bracket are not significantly differ...

Ngày tải lên: 19/02/2014, 19:20

... Spoken Language Translation. Percy Liang, Ben Taskar, and Dan Klein. 2006. Align- ment by agreement. In Proceedings of the Human Language Technology Conference - North American Chapter of the Association ... Meeting of the Association for Com- putational Linguistics. Phillip Koehn, FranzJosef Och, and Daniel Marcu. 2003. Statistical phrase-based translation. In Proceedings of t...

Ngày tải lên: 20/02/2014, 04:20

... instance of each morpheme of the EP can be viewed as an instance of the ambiguous word, thus the training set can be enlarged easily. EP is a solution to data sparseness for lack of human tagging ... relatedness of the senses refers to the similarity of the contexts of the original ambigu- ous word and its EP. The similarity between the words means that...

Ngày tải lên: 20/02/2014, 12:20

... computer and key- board in the English Wikipedia. provides multilingual support for the English, Ger- man, French and Italian Wikipedias and can be eas- ily extended to other languages 4 . 4 Software ... download, and can be accessed using robust Open Source applications, e.g. the MediaWiki software 5 , integrated within a Linux, Apache, MySQL and PHP (LAMP) software bundle. The archi...

Ngày tải lên: 20/02/2014, 12:20

... describe the domain in which the di- alogue system operates (an “in-car” information sys- tem). Then we describe the major components of the system and give examples of their use. We then discuss the ... describes the main components and functionality of the system, as well as the pur- poses and future use of the system, and surveys the research issues involved...

Ngày tải lên: 22/02/2014, 02:20

... A comparison of the structure of the unli- ganded cathepsin B with the structure of the proenzyme, its complexes with chagasin and stefin A shows that the magnitude of the shift of the occlud- ing ... trunk of stefin A can displace the AB CD Fig. 3. The extent of the occluding loop dis- placement in the unliganded and liganded structures. The occluding loop...

Ngày tải lên: 18/02/2014, 04:20