Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt

... establishment of the disease. The uptake of M. tuberculosis by macrophages is associated with a number of early signaling events, such as the recruitment and activation of members of Survival strategies of ... strategies of mycobacteria in host FEBS Journal 277 (2010) 2416–2427 ª 2010 The Authors Journal compilation ª 2010 FEBS 2427 REVIEW ARTICLE Survival mechanisms of...

Ngày tải lên: 16/02/2014, 15:20

... (i.e. deprotonation of C2a-OH of HEThDP and proton- ation of FAD at N5 and N1). The tight and rigid binding of both cofactors excludes a direct carbanion mechanism with covalent linkage between C2a of the HEThDP ... roles of CoA and phosphate for an intimate coupling of electron and acyl group transfer. Viable mechanisms of reduc- tive acetylation in pyruvate dehydrogenase m...

Ngày tải lên: 18/02/2014, 08:20

... M. Erdinc 2 1 Department of Biochemistry, Faculty of Medicine, University of Dicle, Diyarbakır, Turkey, 2 Department of Pharmacology, Faculty of Medicine, University of Dicle, Diyarbakır, Turkey. ... for differentiation and loss of malig- nancy. Study of molecular mechanisms of these processes can provide a possibility to affect progression of tumour. The goal of the p...

Ngày tải lên: 19/02/2014, 07:20

... monitored t he internalization of the Tat peptide by ¯ow cytometry analysis (Fig. 2), a technique allowing the evaluation of the homogeneity of the cellular population i n terms of uptake e f®ciency. ... [9]. However a rightward shift of the s ignal was observed signifying a reduction of the uptake of the Tat peptide at low temperature. Likewise, a threefold r eduction of the...

Ngày tải lên: 21/02/2014, 03:20

... 4% of the total soluble protein content of the cell [48]. Fig. 3. Microbial mechanisms of glyphosate degradation. (A) Two principal pathways of glyphosate degradation are known. Top: cleavage of ... molecular mode of action of glypho- sate and the molecular basis for glyphosate resistance. Structure and function of EPSPS EPSPS catalyzes the transfer of the enolpyruvyl moie...

Ngày tải lên: 14/02/2014, 14:20

... of tau with Fyn-SH3. We also show that tau interacts with the SH2 domain of Fyn, and that this associa- tion, unlike that of Fyn-SH3, is influenced by Fyn-mediated tyrosine phos- phorylation of ... SH3 domain of Fyn binds to proline-rich motifs within the sequence PXXP in interacting pro- teins. Seven such motifs are present in the proline-rich domain of the longest isoform of ta...

Ngày tải lên: 14/02/2014, 14:20

... diffusion method. Two microlitres of protein solution at a concentration of 9 mgÆmL )1 and 2 lL of crystallization solution were equilibrated against 500 lL of reservoir solution. Initial screens ... buffer at pH 6.0 (25 °C). Structural formulas of the substrates are presented. Redox potentials (E°)ofT1 coppers of the laccases and redox potentials of the substrates at pH 4.5 and...

Ngày tải lên: 14/02/2014, 18:20

... reservoir consisted of 500 lL of 0.7 m sodium citrate, 10 mm dithiothreitol and 70 mm Hepes at pH 7.4. Drops consisted of 0.75 l L of importin-a (70-529) at 18 mgÆmL )1 , 0.75 lL of CLIC4 NLS peptide ... Luria–Bertani medium containing 30 lgÆmL )1 of kanamycin. Flasks of 400 mL of Luria– Bertani medium (30 lgÆmL )1 kanamycin) were then inocu- lated with 10 mL of the overnigh...

Ngày tải lên: 14/02/2014, 19:20

... comparison. Effect of geographical variation in dengue virus on the performance of the primer cocktail Each of the four serotypes of dengue virus can be classi- fied into several genotypes, defined as a group of ... Yuriy Fofanov 1,3 and Richard C. Willson 1,7 1 Department of Biology and Biochemistry, University of Houston, TX, USA 2 Department of Chemical and Biomolecular Engin...

Ngày tải lên: 14/02/2014, 19:20

... (Fig. 3A). Three of the ligands, OD2 of Asp165, NE2 of His79 and NE2 of His169, formed an equatorial plane. The other protein ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, ... conformation around the active site of ApeSOD is independent of the presence of a metal cofactor. Figure 3D shows the superimposition of the active site structures of...

Ngày tải lên: 14/02/2014, 22:20