Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

... MLL in human malignancies FEBS Journal 277 (2010) 1822–1831 ª 2010 The Author Journal compilation ª 2010 FEBS 1831 MINIREVIEW Mixed lineage leukemia: roles in human malignancies and potential therapy Rolf ... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN...

Ngày tải lên: 16/02/2014, 14:20

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... selective and inde- pendent roles within the hematopoietic system, main- taining quiescence in HSCs and promoting proliferation in progenitors [23]. Similarly, in an independe...

Ngày tải lên: 16/02/2014, 14:20

... Marschalek R (2010) Mixed lineage leukemia: roles in human malignancies and potential therapy. FEBS J doi:10.1111/j.1742-4658.2010.07608.x. 164 Cosgrove MS & Patel A (2010) Mixed lineage leuke- mia: ... recent clinical trials in epigenetic therapy. Rev Recent Clin Trials 1, 169– 182. 162 Ansari KI & Mandal SS (2010) Mixed lineage leukemia: roles in...

Ngày tải lên: 16/02/2014, 14:20

... domain of the cAMP response element-binding (CREB) binding protein (CBP) [23], a peptide from the Win motif of MLL1 bound to the WD40 repeat protein, WDR5 [24,25] and the C-terminal SET domain in ... required for the structural integrity of the protein, as mutation of any of the cysteine residues involved in zinc coordina- tion results in protein unfolding [22]. The structure con- tai...

Ngày tải lên: 16/02/2014, 14:20

... binding profiles in a time-dependent manner in ERE1 and ERE2 (Fig. 5B). In agreement with the above findings, binding of ERa and ERb was increased in both ERE1 and ERE2 in the presence of E2. Interestingly, ... Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig. 5A, lanes 1–4). The levels of E2-induced binding of ERa and ERb were highe...

Ngày tải lên: 18/02/2014, 14:20

... proteins that bind to biotinylated cell fractions, including the already characterized adhesion heparin-binding haemagglutinin [27]. A B Fig. 5. Saturation curves and critical residues of cell binding. ... show any binding to HepG2 cells or erythrocytes (data not shown). Invasion inhibition assay using HABPs A549 and U937 cell lines were preincubated in the presence of HABP 11024 in...

Ngày tải lên: 18/02/2014, 16:20

... both in the crystalline state (such as quartz) and in the amorphous state (such as opal). Silica ⁄ silicate is widely used in industry and medicine for the fabrication of poly(sili- cate), e.g. in ... of silicatein in spicules and in intra- and extracellular vesicles by TEM immunogold labeling. (i) Association of silicatein with spicules. (A) Strong antibody reactions are...

Ngày tải lên: 18/02/2014, 16:20

... mapping features are all binary. The focusing phrase and its two surrounding words of the input are regarded as the window. The mapping features are defined as the pairs of the output phrase and ... were trained using only the real-error corpus (baseline). • SRC: Trained using only the pseudo-error corpus. • ALL: Trained using the real-error and pseudo- error corpora by simply adding the...

Ngày tải lên: 19/02/2014, 19:20

... structure and binding relations are maintained. Reconstructing this representation requires syntac- tic parallelism (ruling out passive/active and nomi- nalization cases) and can result in violation ... (the use of and in exam- ple 2)) 11, thereby identifying the first clause as a unit for coherence establishment and invoking inte- gration of its propositional representati...

Ngày tải lên: 20/02/2014, 21:20

... enzyme–inhib- itor binding interaction. log K ðappÞ i ¼ log K Ã þ 1: 18Z E Z L ffiffi I p ð7Þ Discussion In this study we have determined that neomycin B and its close structural analog, neamine, are mixed- type noncompetitive ... manifes- ted in Figs 3 and 4. Note that the Lineweaver–Burk plot in Fig. 4 is distinctly nonlinear. The results are illustrated in Fig. 5, in which the w...

Ngày tải lên: 19/02/2014, 06:20