Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

... Bhaumik H3K4 methyltransferases from yeast to human FEBS Journal 277 (2010) 1805–1821 ª 2010 The Authors Journal compilation ª 2010 FEBS 1821 MINIREVIEW Mixed lineage leukemia: histone H3 lysine 4 methyltransferases ... directed towards histone H3 lysine 4 methylation and the enzymes involved in this covalent modification in eukaryotes ranging from yeast...

Ngày tải lên: 16/02/2014, 14:20

... ER, estrogen receptor; ERE, estrogen- response element; H3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL, mixed lineage leukemia histone methylase; NR, nuclear receptor; RNAPII, RNA ... its paralogue MLL4. Proc Natl Acad Sci USA 106, 8513– 8518. 40 Lee S, Lee J, Lee SK & Lee JW (2008) Activating signal cointegrator-2 is an essential adaptor to recruit hist...

Ngày tải lên: 18/02/2014, 14:20

... Struct Mol Biol 14, 1008–1016. 4 Malik S & Bhaumik SR (2010) Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J doi:10.1111/j.1 742 -46 58- 2010.07607.x. 5 ... adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors. Mol Endocrinol 22, 1312–1319. 7 Marschalek R (2010)...

Ngày tải lên: 16/02/2014, 14:20

... glycogen synthase kinase; H3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL, mixed lineage leukemia; NELF, negative elongation factor; PI3K, phosphatidylinositol 3 kinase; P-TEFb, positive ... Taspase1 [11]. This allows it to assembly into a high-molecular mass complex which confers the meth- ylation of histone core particles at histone H3 lysine 4 (H3K4)...

Ngày tải lên: 16/02/2014, 14:20

... possesses H3K4 dimethyltransferase activity. We suggest that the MLL1 SET domain catalyzes monomethylation of histone H3 at lysine 4, which is fol- lowed by transfer of the monomethylated histone H3 to ... can trimethylate H3K4, but not mono- or dimethylate H3K4 [59]. Further experimentation with more quanti- tative techniques to assess the degree of H3K4 methyl- ation will be...

Ngày tải lên: 16/02/2014, 14:20

... 2006) doi:10.1111/j.1 742 -46 58.2006.05316.x We report a detailed kinetic investigation of the aminoglycosides neomycin B and neamine as inhibitors of the lethal factor protease from Bacillus anthracis. Both inhibitors ... shown 1 / [S] 0.00 0.02 0. 04 0.06 0.08 0.10 V / 1 0 2 4 6 8 Fig. 4. Double-reciprocal Lineweaver–Burk plot corresponding to Fig. 3. [S] (µM) 02 040 6080 )s/.u.a(...

Ngày tải lên: 19/02/2014, 06:20

... 1 04 111. 18 Morgan ET (2001) Regulation of cytochrome p450 by inflammatory mediators: why and how? Drug Metab Dispos 29, 207–212. 19 Paine AJ (1995) Heterogeneity of cytochrome P450 and its toxicological ... of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. J Pharmacol Exp Ther 3 04, 1 048 –10 54. 27 Kumar H, Kawai T & Akira S (2009) Toll-like recep- tors and innate im...

Ngày tải lên: 14/02/2014, 18:20

... Japan Fax: +81 744 29 0306 Tel: +81 744 29 8827 E-mail: yama@naramed-u.ac.jp (Received 23 March 2009, revised 2 October 2009, accepted 9 October 2009) doi:10.1111/j.1 742 -46 58.2009.0 743 9.x Increases ... Ca 2+ store potential was proposed [Yamashita M (2006) FEBS Lett 580, 49 79 49 83; Yamashita M (2008) FEBS J 275, 40 22 40 32]. Ca 2+ efflux from the Ca 2+ store and K + counterinflux in...

Ngày tải lên: 16/02/2014, 09:20

... IP 345 Mar CCD 165 mm Unit-cell parameters a (A ˚ ) 1 34. 00 133.69 81.71 b (A ˚ ) 1 34. 00 133.69 122.93 c (A ˚ ) 111.31 111. 24 205 .40 Measured reflections 511 747 644 348 335 330 Multiplicity 4. 3 ... 0.89 84 0.8100 Resolution (A ˚ ) 95 .4 2. 04 94. 5–1.65 50.0–2.57 Last shell (A ˚ ) 2.30–2. 04 1.75–1.65 2.65–2.57 Space group P4 3 2 1 2P4 3 2 1 2P2 1 2 1 2 1 Temperature (K) 100 100 1...

Ngày tải lên: 16/02/2014, 09:20

... adhesion to collagen via integrin alpha2beta1. Blood 102, 2085–2092. 16 Essex DW & Li M (1999) Protein disulphide isomerase mediates platelet aggregation and secretion. Br J Haematol 1 04, 44 8 45 4. 17 ... 277 (2010) 245 4– 246 2 ª 2010 The Authors Journal compilation ª 2010 FEBS 245 9 over two column volumes). BPTI (UniProt ID P009 74) was expressed and purified as described previous...

Ngày tải lên: 16/02/2014, 14:20