Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx

... 158 5–1 596 ª 2010 The Authors Journal compilation ª 2010 FEBS REVIEW ARTICLE Upregulation of the a-secretase ADAM10 – risk or reason for hope? Kristina Endres and Falk Fahrenholz Department of ... intervention within the biosynthetic pathway of ADAM10 is provided by directly interfer- ing with the expression of the gene for ADAM10: the promoter...

Ngày tải lên: 16/02/2014, 09:20

... glioma has important implications for the development of novel glioma therapies. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor superfamily, ... with tremendous therapeutic potential [9]. The correct functioning of the ubiquitin–proteasome pathway is essential for the degradation of the major- ity of intracellul...

Ngày tải lên: 18/02/2014, 17:20

... as the ATP-unbound and Ca 2+ -bound E1Ca 2+ form. In the histogram (Fig. 2A) of the dis- tribution of the height of the projection of the embed- ded molecule above the flat membrane surface, the average ... elevated conformation being independent of ATP concentration and the average lifetime was in the order of ms (Figure 3B,C). Therefore, we propose that SERCA...

Ngày tải lên: 14/02/2014, 14:20

... minireview. The work of S.W. was supported by the Deutsche Forschungsgemeinschaft (We2843 ⁄ 2-1) and BGAG-Stiftung Walter Hesselbach. The work of S.B. is supported by grants from the Deut- sche Forschungsgemeinschaft ... (2011) 119 0–1 202 ª 2011 The Authors Journal compilation ª 2011 FEBS VirB5 then forms a complex with VirB2, which is a key step in the formation of the...

Ngày tải lên: 14/02/2014, 19:20

... 2–3 and 4– 5). Notably, JSP1 seemed to stimulate preferentially the phosphorylation of the p46 isoform of JNK, whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms. ... necessary for the intrinsic phosphatase activity of the enzyme. However, myristoylation determined the subcellular localization of JSP1, and was required for JSP1-i...

Ngày tải lên: 16/02/2014, 14:20

... develop- ment. Indeed, HSF4 is crucial for development of the lens and maintenance of the olfactory epithelium [102]. The first evidence for a developmental function of HSF4 was provided by population ... development, the trimeric form of HSF4 increases, while the levels of HSF1 and HSF2 are reduced [102]. In the olfactory epithelium of 3–6 -week-old mice, the e...

Ngày tải lên: 18/02/2014, 04:20

... investigate the biological importance of these proteins, the Center for Eukaryotic Structural Genomics (CESG) at the University of Madison-Wisconsin has established plat- forms for protein structure ... 000 torsion-angle dynamics time steps per conformer was performed during the cyana structure calculations. In the final cycle of the cyana protocol, 100 conformers were ge...

Ngày tải lên: 18/02/2014, 14:20

... summary, MDL1 forms a homodimeric complex independent of its subcellular targeting. The ATPase activity of ABC half-transporters is critically dependent on the complex formation. We therefore compared the ... and -11 relative to the cleavage site. The leader sequence inter- acts with the TOM receptor, responsible for the trans- location of the preproteins to the tran...

Ngày tải lên: 18/02/2014, 16:20

... analy- ses of Olvas–GFP, Nanos–GFP and Tudor–GFP were performed for the granule (B). Each curve is the mean of 10 independent mea- surements. The bleached position is indicated by the white circle (inset). ... in the nuage for seconds, and that Olvas–GFP in the cytosol diffuses rather freely. Although the nuage has been analyzed as an important structure for the form...

Ngày tải lên: 18/02/2014, 16:20

... registered. The K d values were estimated by fitting the fluorescence data to a theoretical equation for a 1 : 1 complex. The K d determina- tions for FNR–Fd were performed either in the absence or presence ... the distribution of conformations, and thus promoting the catalytic reaction [54]. Residues C266 and L268 may influence the conformational freedom of the sub- st...

Ngày tải lên: 18/02/2014, 17:20