Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt

... antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid Bilal A. Azakir, Guillaume Desrochers and Annie Angers De ´ partement ... tBid levels and the ubiquitin ligase activity of Itch. In this study, we first examined the ability of Itch to interact w...

Ngày tải lên: 16/02/2014, 09:20

... product by isoform 2 mRNA (Fig. 4B). The product by isoform 1 mRNA was smaller than the isoform 2 product. The multiple bands may be explained by incomplete translation from truncated mRNA synthesized ... RT-PCR to study the tissue-specific use of each promoter. We show the translation initiation site of isoform 2 and different intracellular distribution of isoforms 1...

Ngày tải lên: 19/02/2014, 06:20

... the scale of the Bard’s genera- tivity, and the quality of its insights. 5 Empirical Evaluation The vastness of the web, captured in the large- scale sample that is the Google ngrams, means the Jigsaw ... instances of the patterns “as ADJ and * as” and “as * and ADJ as” from Google, noting the combinations that are found and their frequencies. These frequ...

Ngày tải lên: 20/02/2014, 05:20

... proliferation and cell death [27]. The functional roles of the activation of these kinases are often con- troversially discussed. The ERK1 ⁄ 2 cascade is regarded to be the main method of transmission ... translocation and cytochrome c release are suppressed by NAC To investigate the effects of ROS on Bax translocation and cytochrome c release, the levels of Bax...

Ngày tải lên: 18/02/2014, 13:20

... Effect of MAFP on the growth of U937 cells. (A) Dose– response curve for the effect of MAFP on the Ca 2+ -independent PLA 2 activity of U937 cell homogenates. The substrate was pre- sented in the ... better with the kinetics of its catabolism rather than synthesis [23,33,35], and the involvement of iPLA 2 -VIA in the homeostatic regulation of mem- brane pho...

Ngày tải lên: 18/02/2014, 17:20

... carried out a total of 572 conversa- tions with the system. Because of the variety of pos- sible exercise barriers known by the system (52 in total) and the fact that some of these barriers are more ... (composed of the values of the features listed in Table 2). For instance, in the p a policy, the deci- sion in the last row of the table (give a joke or n...

Ngày tải lên: 20/02/2014, 12:20

... an unit and any other domains, domainj seems to be the domain of unit~. The system se- lects the domain which is the largest of all sim- ilarities in N of domains as the domain of the unit ... firstly, the system divides radio news into segments according to the length of pauses. We call the segments units. The domain which has the largest similarity be...

Ngày tải lên: 20/02/2014, 18:20

... than the conviction on the part of the terminal operators that they are in control of the system and not the system in control of them. Equally, nothing can be more damaging to satisfactory ... regardless of how well all other aspects of the imple- mentatlon have been handled, than the operator's con- viction that the terminal and thus ~he @~t.e~ ~re i...

Ngày tải lên: 21/02/2014, 20:20

... 4). Both the heterogeneous bands at  80 kDa and the group of bands at  65 kDa were recognized by the anti-HA serum (Fig. 4B, lanes 4 and 5). As these proteins are also recognized by the anti-FLAG serum, ... suggesting that the N-terminal portion of the protein containing the HA epitope was lost from these proteins by pro- teolysis. To determine which of the...

Ngày tải lên: 18/02/2014, 08:20

... stress conditions. Degradation pathway of Egd2 ubiquitinated by Rsp5 To explore the pathway involved in degradation of the ubiquitinated Egd2, we first examined the protein lev- els of Egd2 by western ... regulate the expression of many proteins at the transcriptional and post-translational level, because Rsp5 is known to regulate the activity of the RNA pol...

Ngày tải lên: 18/02/2014, 11:20