Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... Kinetic analysis of epidermal growth factor receptor somatic mutant proteins showsincreased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res66, ... JapanIdentification of epidermal growth factor, epidermal growth factor receptor and ERBB family proteins Epidermal growth factor (EGF) was originally isolatedby Stanley Cohen in 1962 as a protein extracted ... Mutations of the epi-dermal growth factor receptor gene and related genes asdeterminants of epidermal growth factor receptor tyro-sine kinase inhibitors sensitivity in lung cancer. CancerSci...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... MINIREVIEW Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy Isamu OkamotoDepartment of Medical Oncology, Kinki University School of Medicine, ... sensitivity to therapy with mAb to epidermal growth factor receptor in colorectal cancerCetuximab is a chimeric mouse–human mAb that tar-gets the extracellular domain of the epidermal growth factor receptor ... compete with ATP for binding to the tyrosine kinase pocket of the receptor, therebyinhibiting receptor tyrosine kinase activity and EGFRsignaling pathways (Fig. 1). Early clinical studiesshowed...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... thatincludes a DNA-binding domain, a ligand-bindingdomain and a transactivation domain. The DNA-bind-ing domain is responsible for DNA binding specificityand dimerization, and the ligand-binding ... selective and inde-pendent roles within the hematopoietic system, main-taining quiescence in HSCs and promoting proliferation in progenitors [23]. Similarly, in an independent studyusing a conditional ... domains areinvolved in binding DNA with low sequence specificity. LXXLL domains (also known as the NR box) are involved in interaction with nuclear receptor (NR). Plant homodomain (PHD) and RING...
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Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc
... cobalamin; intrinsic factor; recom-binant.Vitamin B12(cobalamin, Cbl) is the most complex of thevitamins [1]; it is a complicated system with three trans-porting proteins and several receptors ... IF.Binding of IF to cubilinSpecific binding of IF–Cbl complex to the immobilized receptor cubilin was conducted on a BIAcore 2000equipment as described earlier [24]. In short, recombinantcubilin ... [23].Binding of IF to the specific receptor cubilinWhen IF–Cbl complexes from different sources wereexposed to the IF-specific receptor cubilin immobilized ona detector chip [4], all proteins...
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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... listed in Table 1, we blocked EGFR signaling with gefitinib.Gefitinib is an inhibitor of tyrosine kinase that competeswith ATP for binding to the intracellular kinase domain,preventing receptor ... diseases. In severe cases,aberrant growth factor signaling may even give rise to tumors. Among these pathways, epidermal growth Keywords epidermal growth factor receptor; lungneoplasm; metastasis; ... cancers To gain further insights into the role of miR-125a-5p in lung carcinogenesis and to examine the clinical rele-vance of our findings, we investigated the expressionof miR-125a-5p in a panel...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships docx
... domain–domain interactions.AbbreviationsAD, Alzheimer’s disease; DTNB, 5,5¢-dithiobis-(1-nitrobenzoic acid); GIF, neuronal growth- inhibitory factor; hGIF, human neuronal growth- inhibitory factor; ... a-domain is not directlyinvolved in neuronal growth- inhibitory activity[5,6,17,18]. However, it has been well documented thatthe two domains of MT do not work independently,and domain–domain interactions ... GIF remains elusive. It has been reported that theneuronal growth- inhibitory activity of GIF is mainlyassociated with its b-domain, and the single a-domaindoes not show any growth- inhibitory...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc
... growth- inhibitory factor (GIF) [1] because of thediscovery that it is a factor in brain extract with theability to inhibit neuronal outgrowth. Moreover, MT3or GIF was reported to be down-regulated in ... [M(II)3-Cys9], including three bridging and six terminal cyste-ines. The C-terminal a-domain (amino acids 31-61)binds four divalent metal ions by 11 deprotonatedcysteines in an adamantane-like ... dynamics shouldalso result in a faster metal transfer from and to MT3and hence is in line with an involvement in the traffick-ing of Zn(II) in particular in zinc-containing neurons[41]. However,...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... MINIREVIEWNeuronal growth- inhibitory factor (metallothionein-3):evaluation of the biological function of growth- inhibitory factor in the injured and neurodegenerative brainClaire ... distinct biological properties. In this review, we examinethe recent developments regarding the function of neuronal growth- inhibi-tory factor within the brain, particularly in response to brain ... are those known to store zinc in their axon terminals [7]. In addition, thesynthesis of GIF within cultured cells led to a signifi-cant increase in intracellular Zn(II) stores within thosecells...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, ... con-centrations of tumor necrosis factor- a and interleukin-6, and increasedhepatic mRNA levels of tumor necrosis factor- a and interleukin-6 weredecreased by depletion of KCs. Our findings suggest ... these receptors activates in amma-tory responses characterized by the release of a widerange of proinflammatory cytokines, including IL-6 Sham GdCl3CLP GdCl3 + CLPHMGB1iNOSβ-actinFig....
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Từ khóa: tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngbáo cáo khoa học số loài quý hiếm tại vườn quốc gia ba bểtai lieu bao cao thuc tap khoa co khitai lieu bao cao thuc tap tai khoa duoc benh vienBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM