Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes pdf

... typically in the range 2–3 mm [26]. Finding experimental evidence that electrical cou- pling is the key ‘spring’ interlinking the Ca 2+ stores has involved repeating the decoupling experiment of Fig. ... store Ca 2+ release and resulting slow-wave potentials (Fig. 2A). Application of the caffeine-containing physiological sal- ine solution to the central region of a single bundle str...

Ngày tải lên: 16/02/2014, 09:20

... MINIREVIEW Synchronization of Ca 2+ oscillations: involvement of ATP release in astrocytes Schuichi Koizumi Department of Pharmacology, Faculty of Medicine, University of Yamanashi, Japan Introduction Glia, ... receptors, suggesting the involvement of multiple pathways in the release. In addition to these, the release of ATP is partly dependent on Ca 2+...

Ngày tải lên: 16/02/2014, 09:20

... synchronous increases in intracellular [Ca 2+ ], as described below. Synchronous increases in intracellular [Ca 2+ ] and disassembly of cadherin–catenin complexes The cytoplasmic domain of cadherin interacts ... with F-actin via b-catenin and a-catenin; b-catenin binds to cadherin and a-catenin, which in turn interacts with F-actin (Fig. 3A) [24]. Thus b-catenin plays a pivotal role...

Ngày tải lên: 16/02/2014, 09:20

... containing mutations of the second or third miR-23a binding regions. (C) Similarly, overexpression of miR-23a failed to suppress the EGFP intensity in the reporter vector containing mutation of ... reporter vector containing a muta- tion of the first binding site showed no response to altered miR-23a expression, suggesting that the first binding site in the 3¢ UTR of IL6R mRNA mai...

Ngày tải lên: 18/02/2014, 04:20

... complex. The amino acid residues that determine the zymo- genicity of free FVIIa are as interesting as those involved in the TF-induced allostery. Amino acid resi- dues in FVIIa that are involved in the ... for TF binding and ⁄ or the cofactor effect [13]. In terms of intramolecular propagation of the TF-induced signal, the most interesting mutations are those that only affect a...

Ngày tải lên: 18/02/2014, 08:20

... Universite ´ Paris, France Introduction Modification of the chirality of a single aminoacyl resi- due within a peptide chain is a subtle and intriguing mechanism that remains poorly known to date, ... arborizations containing D-Trp4 VIH (green) and D-Phe3 CHH (red). (H) Enlargement of axon terminals in the sinus gland with labelling as in (G). Peptidyl isomerization in neuroendocri...

Ngày tải lên: 18/02/2014, 11:20

... presence of E2. Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig. 5A, lanes 1–4). The levels of E2-induced binding of ERa and ERb were higher in ERE2 than in ERE1. ... binding profiles in a time-dependent manner in ERE1 and ERE2 (Fig. 5B). In agreement with the above findings, binding of ERa and ERb was increased in both ERE1 and E...

Ngày tải lên: 18/02/2014, 14:20

... rate of 1.0 mLÆmin )1 . Previously, the product of the enzymatic reaction of brassinin, ind- olyl-3-methanamine (3), was determined indirectly by reverse-phase HPLC after acetylation of brassinin ... phyto- alexin that displayed an inhibitory effect was further examined in order to determine the type of inhibition and the K i using brassinin (0.10–0.40 mm) as a sub- strate in th...

Ngày tải lên: 18/02/2014, 14:20

... CA protein sequences. Iden- tical and similar amino acids shared by at least 50% of the isoforms are shown in black and grey, respectively. Histidine residues involved in zinc binding in the catalytic ... posi- tions 94, 96 and 119 in CAII from Homo sapiens) which are directly involved in binding the zinc cofac- tor, are conserved in the two R. pachyptila sequences (positions la...

Ngày tải lên: 18/02/2014, 16:20

... dis- tribution of the energy between the overall tumbling and the internal mobility, and is indicative of the degree of internal restraint of each 15 N– 1 H vector motion. In Fig. 4, most of the points ... occurrence of either a kinking or tightening of the local geometry. A similar discontinuity had been noted in solution also in the Antp HD [8,9] and the Antp (C39S) HD [...

Ngày tải lên: 18/02/2014, 16:20