... of Physiology and Pharmacology, University of Calgary, Alberta, Canada2 School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, AustraliaLong-range signalingBiological organs ... 2009)doi:10.1111/j.1742-4658.2009.07437.xEntrained oscillations in Ca2+underlie many biological pacemaking phe-nomena. In this article, we review a long-range signaling mechanism in smooth muscle that results in global outcomes of ... depolarizations that drive rhythmic contractions of lymphatic smooth muscle. The main feature of this signaling mechanism is a coupled oscillator-based synchronization of Ca2+oscillations across...