Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx

... membrane proteins to migrate apically. Transcytosis of integrins would therefore enable H. pylori with the intriguing possibility of targeting the integrin b 1 receptor at api- cal membranes (Fig. 1). The ... M (2008) Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol 10, 1573–1581. 7 Hatakeyama M (2008) SagA of CagA in Helico- bacte...

Ngày tải lên: 14/02/2014, 19:20

... mediator of lethal sepsis, triggering the production of proinflammatory cytokines and liver injury [13]. Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform ... [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23]. Activated KCs cause oxidative stress on...

Ngày tải lên: 14/02/2014, 18:20

... survival resulting from activation of PPARb. Activation of PPARb by LD induces CERK mRNA expression and increases CerK activity in SP1 cells To investigate the role of CerK and its regulation of Cer ... CERK- negative were obtained in ChIP DNA, indicating that the binding of putative CERK-PPRE to PPARb is specific. Furthermore, the interaction between PPARb and CERK was c...

Ngày tải lên: 18/02/2014, 18:20

... amounts of protein from 3Y1-Ad12 cell lysates confirmed the absence of cathepsin D in nontransfected cells, and the presence of both the 31 kDa mature cathepsin D and the 45 kDa procathepsin D in cathepsin ... bafilomycin and the cathepsin D inhibitor pepstatin A partially inhibited, both in vivo and in vitro, the cAMP response to cholera toxin. This cathepsin D-depend...

Ngày tải lên: 19/02/2014, 02:20

... survival. They bind and activate a specific tyrosine kinase receptor that is coupled to multiple intracellular signaling pathways [17,18]. Activation of tyrosine kinase receptors is involved in ... family proteins, is induced through MAP kinase activation, allowing transactiva- tion of genes containing AP1-binding elements. How- ever, it is not known whether EGF is capable of protectin...

Ngày tải lên: 19/02/2014, 06:20

... mutant proteins. This was interpreted as a lack of fosfomycin binding to these mutant proteins [12]. Binding of fosfomycin to either wild -type MurA or the K22 mutant proteins in the absence of UDPNAG is not ... form of the protein. The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine 120 in the conformational proc...

Ngày tải lên: 19/02/2014, 13:20

... large in uence on conformation of inhibitor main chain. Thus, different inhibitors differ not only in t he binding affinity, bu t a lso in the degree o f freedom of the inhibitor inside the binding tunnel. ... 2.0 A ˚ . The overall layout of the inhibitor in the pr otease binding site is very similar for all the compared inhibitors. The side chains of all the i...

Ngày tải lên: 19/02/2014, 16:20

... with the wild -type receptor (Fig. 4B). We wondered whether shedding of the ectodomain would modify the trafficking of the receptor. Therefore, we studied the comparative internalization of the wild -type ... transmembrane domain of the receptor [7,34,35]. The current hypothesis maintains that constitutively activated receptors release the conformational constraints...

Ngày tải lên: 21/02/2014, 00:20

... (long-distance move- ment of the N-domain and rotational motion of the A-domain) of SERCA during the ATP-mediated ion transport reaction [14,16–19]. The single line scanning method [8,15], in which an AFM ... Typical single line scan data obtained with buffer conditions. (A) Representative single line scan graphs obtained at increasing ATP concentration in the range 0–100...

Ngày tải lên: 14/02/2014, 14:20

... significant production of P i in the vicinity of the ATPase within the matrix. CYPD ablation or its inhibition by cyclosporin A increases the rate of respiration stimulated by arsenate in intact mitochondria Regarding ... and unbinding by cyclosporin A was demonstrated in the present study in intact mitochondria. This is the result of an imposing role of the A...

Ngày tải lên: 14/02/2014, 19:20