... transcription, were increased in response toEGF. Pretreatment of the cells with PD98059, an inhibitor of MAP kinasekinase, inhibited the EGF-induced c-Fos and c-Jun expression, AP1 DNAbinding, Bcl-XLexpression, ... protein-tyrosine kinases in vivo and in vitro. Cell 57, 1109–1122.18 Holgado-Madruga M, Emlet DR, Moscatello DK,Godwin AK & Wong AJ (1996) A Grb2-associateddocking protein in EGF- and insulin-receptor ... of c-Fos, a member of the Fosfamily, AP1 may be implicated in the transcription of bcl-XLinduced by EGF. We then studied the effects of EGF on AP1 DNA binding in TMK-1 cells. The resultsof...