Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... compilation ª 2011 FEBS MINIREVIEW TEC family kinases in health and disease – loss -of- function of BTK and ITK and the gain -of- function fusions ITK SYK and BTK SYK Alamdar Hussain 1,2, *, Liang Yu 1,3, *, ... phosphorylation levels of BTK SYK. ITK SYK was highly phosphorylated in both COS7 and 293T cells and did not vary like BTK SYK; theref...

Ngày tải lên: 14/02/2014, 18:20

... on the pro- blem of identifying and organizing into a useful database structure the different linguistic consti- tuents of the candidate predications, a phase simi- lar to what are known in the ... Mining metalinguistic activity in corpora to create lexical resources using Information Extraction techniques: the MOP system Carlos Rodríguez Penagos Language Engineering G...

Ngày tải lên: 20/02/2014, 15:20

... RPE65c was incubated with liposomes con- taining atRE (A), liposomes containing atRE in the presence of 1m M bipyridine (B) and liposomes containing atRE, in the presence of 1 m M bipyridine and 6 ... magnification images of the boxed area in (B4) showing RPE65c staining (B5), GS staining (B6), merged RPE65c and GS staining (B7), and DAPI staining (B8), respectively....

Ngày tải lên: 14/02/2014, 14:20

... describe here the phenotype of mutant mouse strain 0283. This strain exhibited a phenotype indicative of resistance to diet-induced and genetic obesity. The mutation of the 0283 strain is in the RMI1 ... signifi- cantly in the liver and intra-abdominal fat of the obese phenotype mice; however, that in the skeletal muscle did not increase, and that in the s...

Ngày tải lên: 16/02/2014, 09:20

... involved in neurological dis- eases. Here, we discuss the current understanding of the role of SREBPs in glia–neuron interactions in health and disease. Role of Schwann cell SREBPs in myelination The ... FEBS sion of SREBP-1 in the brain does increase in mice during aging [39], a phenomenon also observed in the peripheral nerve [3]. The meaning of thi...

Ngày tải lên: 18/02/2014, 13:20

... reaction of the luciferin ⁄ luciferase mixture, energy donor (ATP) and oxygen results in the emission of light. The intensity of the bioluminescence was detected using a luminometer, and the mitochondrial ... 2007) doi:10.1111/j.1742-4658.2007.06051.x The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-...

Ngày tải lên: 18/02/2014, 16:20

... loosely arranged, and the densities correspond to the N- and C-terminal helices of the c ring, respectively. The C-terminal helices show a clear handedness, and two of the rings face in the opposite ... represent the view from the cytoplasm (open rings in AFM) and the red ones the view from the extracellular side (smaller, closed rings in Fig. 3). The...

Ngày tải lên: 18/02/2014, 17:20

... Follistatin, Chordin and Noggin [12]. These proteins are antagonists of BMP and other members of the TGF-b family, binding to and inhibit- ing these signaling molecules from binding to their receptors ... protein 2 in the early devel- opment of Xenopus laevis. Mech Dev 52, 35 7–3 70. 7 Fainsod A, Steinbeisser H & De Robertis EM (1994) On the function of BMP-4 in...

Ngày tải lên: 19/02/2014, 00:20

... cell lines expressing both isoforms of KLK11, and used human a neuroblastoma cell line, KP-N-YN, because of the transfection efficiency and expression of both KLK11 isoform 1 and isoform 2 in this ... the regulation and characteristics of these isoforms are unknown. We identified the first three exons (1a, 1b, and 1c) by determining their transcription initiation sites....

Ngày tải lên: 19/02/2014, 06:20

... within the intermembrane space, and the proteolysis must therefore represent a loss of 2 kDa from the N-terminus. Given there are seven arginine and lysine residues spread through the N-terminal stretch ... segments, in support of the behavior of the protein in Triton X-114. The transmembrane segments corresponding to residues 7 1–9 0 and 10 4–1 19 are con-...

Ngày tải lên: 19/02/2014, 07:20