... mutant disease- causing protein
The principal disease- causing proteins, beta-
amyloid and tau for Alzheimer’s (Fassbender
et al., 2001; Mandelkow and Mandelkow,
1998), alpha-synuclein and parkin ... early and massive degen-
eration in Parkinson’s disease.
Parkinson’s disease (PD) is a progressive neu-
rodegenerative disease which afflicts approx-
imately 1% of the populatio...
... early Parkinson’s disease
AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE 9
Figure 11 Posture in later-stage Parkinson’s disease
10 AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE
Figure 12 Parkinson’s ... PARKINSON’S DISEASE
Figure 16 Parkinson’s disease: dystonic posturing of the big toe secondary to dopa therapy
AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE...
... respectively;
and my family—my wife Wei, our kids, our parents Donna and Robert and Pei and
Robert, and my sibs Anne, Beth, and Mikhael, whose contributions of friendship,
love, understanding of ... age -related
cognitive decline and early dementia, and differentiating among different types of
D.H.S. Silverman (ed.), PET in the Evaluation of Alzheimer’s Disease and R...
... “Delirium, Dementia,
and Amnestic and Other Cognitive
Disorders and Mental Disorders due to a
General Medical Condition” in
Comprehensive Textbook of Psychiatry,
e
ds.
Harold I. Kaplan and, Benjamin ... Concepts,
Diagnosis, and Management” in
Handbook of Dementia,eds.Peter
Lic
ht
neberg, Daniel L. Murman, and
Alan M. Mellow (Hoboken, N.J.: Wiley
and Sons, 2003): 149–165.
10....
... nuisance.
Balance and Movement Difficulties
People with advanced Parkinson’s disease find com-
mon physical maneuvers, such as rising to a standing po-
88 / SIGNS AND SYMPTOMS OF PARKINSON’S DISEASE
sition ... decades, Parkinson’s disease has
become a disorder that does not prevent people from liv-
ing productive and satisfying lives for many years. Un-
derstanding the symptom...
... Epidemiology and Genetics of Parkinson’s Disease 85
5 Epidemiology and Genetics
of Parkinson’s Disease
Demetrius M. (Jim) Maraganore, MD
CONTENTS
HOW COMMON IS PARKINSON’S DISEASE, AND WHAT IS ... RISK FACTORS FOR PARKINSON’S DISEASE?
W
HAT ARE THE PROTECTIVE FACTORS
AGAINST PARKINSON’S DISEASE?
W
HAT CAUSES PARKINSON’S DISEASE (CLUES FROM
EPIDEMIOLOGY)?
C
AN PAR...
... the United States
and in several foreign countries.
14
LIFE OUT OF FOCUS: ALZHEIMER’S DISEASE AND RELATED DISORDERS
The children were all grown and on their own when her husband
retired from the ... orientation, and communication skills worsened. Worried friends
would telephone her husband, describing Mary’s dangerous driving habits
16
LIFE OUT OF FOCUS: ALZHEIMER’S DISEASE A...