... eyes of rat, cow, monkey and rab-bit. In the adult rat eye, PDGF-D is localized to the stroma of iris and ciliar body in the anterior segment, and to the outer plexiform layer of the retina contain-ing ... withadenovirus-containing PDGF-D, resulting in peri-vascular lymphoid cell infiltrates of the lung and fibro-sis in the liver [110].Conclusions The novel members, PDGF-C and -D, of the PDGFsubfamily of the ... sequences [41] but contain dibasiccleavage sites for proteolytic removal of the CUBdomains and thereby activation of the growth factordomains. PDGF-C and -D contain both the CUB and growth factor...