... The binding of ZIP to Grb14, byrecruiting protein kinase Cf, enhances the serine phos-phorylation of Grb14 and its inhibitory effect on IRkinase and insulin signaling [10]. The interaction of Grb14 ... (a)protein kinase Cf interacting protein (ZIP), an adaptorprotein that binds to the PIR domain of Grb14and mediates the assembly of a protein kinaseCf–ZIP–Grb14 heterotrimer [10]; (b) insulin receptorsubstrate-1 ... S-transferase; IR, insulin receptor; IRS-1, insulin receptor substrate-1; IRb, insulin receptorb-subunit; PDK-1, 3-phosphoinositide-dependent kinase-1; PI3-kinase, phosphoinositide-3-kinase; PIR, phosphorylated...