Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 65) doc

... into a human body is metabolized almost entirely; it is excreted into urine in the forms of 7-hydroxywarfarin, 6-hydroxywarfarin and warfarin alcohol. For analysis of such metabolites in urine, ... analysis of warfarin, coumatetralyl is good as IS. TIC for the 3 standard coumarin rodenticides (anticoagulants) and SIM chromatogram for the serum extract of a patient un...

Ngày tải lên: 26/01/2014, 19:20

... chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS). A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam and 50 ng of alprazolam were added ... described. In addition, the LC/MS analysis of triazolam, and its metabolites 4-hydroxy- triazolam and α-hydroxytriazolam is also presented. GC/MS analysis of ben...

Ngày tải lên: 15/12/2013, 12:15

... dissolved in 100 µL methanol, and a 1- L aliquot of it is injected into GC. For quantitation, the peak area ratio of a target compound to IS is obtained. vi. For quantitative analysis, a 1 0- L of IS ... method using a DB-1 capillary column. Many compounds ap- peared as sharp peaks. With an intermediately polar DB-17 capillary column, sharp peaks also appeared. By usi...

Ngày tải lên: 15/12/2013, 12:15

... Shinozuka T, Terada M (1995) Standard methods of chemical analysis in poisoning VII, analgesics and anti- pyretics, the 115th Annual Meeting of the Pharmaceutical Society of Japan, the data of ... Table 2.1) are non-steroidal and anti- in ammatory drugs. As one of mechanisms of their pharmacological actions, inhibition of prostaglandin biosynthesis can be mentioned. A...

Ngày tải lên: 15/12/2013, 12:15

... admission. Notes a)  e APAP metabolites (APAP-glucuronide, catechol 3-hydroxyaminophen, APAP-N-sul- fate, 3-cysteinyl APAP, 3-methoxy APAP and APAP-3-mercapturic acid) are not commer- cially available; ... metabolites in urine [4] Reagents and their preparation • APAP (Eastmann, Rochester, NY, USA) and APAP metabolites a (APAP-glucuronide, cat- echol 3-hydroxyaminophen, APAP-N-sul...

Ngày tải lên: 15/12/2013, 12:15

... described in Chapter 4 can be also used for analysis of sali- cylic acid. Methyl salicylate, being used as a topical analgesic-antiphlogistic drug, is also me- tabolized into salicylic acid; therefore, ... tinnitus, bradyacusia, amblyopia and sweating [1]. For analysis of salicylic acid, HPLC methods were reported [2–7]. In this chapter, a method for HPLC analysis of s...

Ngày tải lên: 24/12/2013, 18:15

... phenylbutazone, mefenamic acid and ca eine.  e total analysis time per sample was less than 25 min. HPLC-UV analysis of cephem antibiotics in plasma with a column-switching system 400 β-Lactam antibiotics Poisoning ... Application of ion-exchange cartridge clean-up in food analysis. IV. Confirmatory assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacil...

Ngày tải lên: 24/12/2013, 18:15

... wrist of about 4 cm length; X-ray photographs, no  nding in the chest and intestinal gas observable in the abdomen. A er admission, gastrolavage and administration of activated charcoal and ... 9,10-dimethoxy-2-anthracene sulfonate (DMAS) as a  uorogenic reagent with excitation at 383 nm and emission at 459 nm. Poisoning case, and toxic and fatal concentrations Pois...

Ngày tải lên: 24/12/2013, 18:15

... Poisons in Humans A Handbook of Practical Analysis Osamu Suzuki and Kanako Watanabe Drugs and Poisons in Humans A Handbook of Practical Analysis With 236 Figures and 90 Tables 123 Prof. Osamu ... Suzuki and Dr. Watanabe have gathered an extensive array of methods for the measure- ment of xenobiotics and metabolites in biological matrices. Dr...

Ngày tải lên: 22/01/2014, 00:20

... superior vena cava and aorta [31]. Postmortem diff usion of drugs from the trachea into heart blood 22 Pitfalls and cautions in analysis of drugs and poisons In Japan, Xylocaine TM jelly is usually ... during in vitro storage of specimens obtained from a nitrazepam user at autopsy Specimen Immediately after autopsy 10 days after autopsy* Nitrazepam 7-Aminonitrazep...

Ngày tải lên: 22/01/2014, 00:20