... carcinomas; IAP, inhibitor of apoptosis protein; JNK, c-Jun NH2-terminal kinase; KIP, kinase inhibitor proteins; MEK,MAPK ⁄ ERK kinase; MKK, MAPK kinase; MKP-1, mitogen-activated protein kinase ... non-small cell lung cancer; Pak1, p21-activated kinase 1; PI3K, phosphatidylinositol 3- kinase; PUMA, p 53 up-regulated modulator of apoptosis; RB, retinoblastoma; TKI, tyrosine kinase inhibitor. 31 6 ... JapanIntroductionThe epidermal growth factor receptor (EGFR) is com-posed of an extracellular ligand-binding domain, atransmembrane domain and an intracellular tyrosinekinase domain. The binding...